Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

Martin Irmler, Romina J. G. Gentier, Frank J. A. Dennissen, Holger Schulz, Ines Bolle, Sabine M. Hoelter, Magdalena Kallnik, Jing Jun Cheng, Martin Klingenspor, Jan Rozman, Nicole Ehrhardt, Denise J. H. P. Hermes, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Helmut E. Meyer, David A. Hopkins, Fred W. Van Leeuwen, Johannes Beckers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)187-197
JournalActa Neuropathologica
Issue number2
Publication statusPublished - Aug 2012


  • Alzheimer's disease (AD)
  • Mouse model
  • Ubiquitin B (UBB+1)
  • Ubiquitin-proteasome system (UPS)
  • Hypoxic response
  • Central breathing control

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