Long-term outcome of sacral neuromodulation for chronic refractory constipation

Yasuko Maeda*, Michael A. Kamm, Carolynne J. Vaizey, Klaus E. Matzel, Claes Johansson, Harald Rosen, Cornelius G. Baeten, Soren Laurberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Web of Science)

Abstract

Purpose Sacral neuromodulation has been reported as a treatment for severe idiopathic constipation. This study aimed to evaluate the long-term effects of sacral neuromodulation by following patients who participated in a prospective, open-label, multicentre study up to 5 years.

Methods Patients were followed up at 1, 3, 6, 12, 24, 36, 48 and 60 months. Symptoms and quality of life were assessed using bowel diary, the Cleveland Clinic constipation score and the Short Form-36 quality-of-life scale.

Results Sixty-two patients (7 male, median age 40 years) underwent test stimulation, and 45 proceeded to permanent implantation. Twenty-seven patients exited the study (7 withdrawn consent, 7 loss of efficacy, 6 site-specific reasons, 4 withdrew other reasons, 2 lost to follow-up, 1 prior to follow-up). Eighteen patients (29%) attended 60-month follow-up. In 10 patients who submitted bowel diary, their improvement of symptoms was sustained: the number of defecations per week (4.1 +/- 3.7 vs 8.1 +/- 3.4, mean +/- standard deviation, p <0.001, baseline vs 60 months) and sensation of incomplete emptying (0.8 +/- 0.3 vs 0.2 +/- 0.1, p = 0.002). In 14 patients (23%) with Cleveland Clinic constipation score, improvement was sustained at 60 months [17.9 +/- 4.4 (baseline) to 10.4 +/- 4.1, p <0.001]. Some 103 device-related adverse events were reported in 27 (61%).

Conclusion Benefit from sacral neuromodulation in the long-term was observed in a small minority of patients with intractable constipation. The results should be interpreted with caution given the high dropout and complication rate during the follow-up period.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalTechniques in coloproctology
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Sacral neuromodulation
  • Sacral nerve stimulation
  • Constipation
  • SLOW TRANSIT CONSTIPATION
  • NERVE-STIMULATION
  • DOUBLE-BLIND
  • IDIOPATHIC CONSTIPATION
  • CONTROLLED CROSSOVER
  • CONTROLLED-TRIAL
  • BIOFEEDBACK
  • EFFICACY

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