Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight

Jonneke J. Hollanders; Nina Schaefer; Sylvia M. van der Pal; Jaap Oosterlaan; Joost Rotteveel; M. J. J. Finken; E. T. M. Hille; C. H. de Groot; H. Kloosterboer-Boerrigter; A. L. den Ouden; A. Rijpstra; S. P. Verloove-Vanhorick; J. A. Vogelaar; J. H. Kok; A. Ilsen; M. van der Lans; W. J. C. Boelen-van der Loo; T. Lundqvist; H. S. A. Heymans; E. J. Duiverman; W. B. Geven; M. L. Duiverman; L. I. Geven; E. J. L. E. Vrijlandt; A. L. M. Mulder; A. Gerver; L. A. A. Kollee; L. Reijmers; R. Sonnemans; J. M. Wit; F. W. Dekker; N. Weisglas-Kuperus; M. G. Keijzer-Veen; A. J. van der Heijden; J. B. van Goudoever; M. M. van Weissenbruch; A. Cranendonk; H. A. Delemarre-van de Waal; L. de Groot; J. F. Samsom; L. S. de Vries; K. J. Rademaker; E. Moerman; M. Voogsgeerd; M. J. K. de Kleine; P. Andriessen; C. C. M. Dielissen-van Helvoirt; I. Mohamed; H. L. M. van Straaten; Dutch POPS-19 Collaborative Study Group

doi:10.1159/000495133

Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight

Jonneke J. Hollanders^*, Nina Schaefer, Sylvia M. van der Pal, Jaap Oosterlaan, Joost Rotteveel, M. J. J. Finken, E. T. M. Hille, C. H. de Groot, H. Kloosterboer-Boerrigter, A. L. den Ouden, A. Rijpstra, S. P. Verloove-Vanhorick, J. A. Vogelaar, J. H. Kok, A. Ilsen, M. van der Lans, W. J. C. Boelen-van der Loo, T. Lundqvist, H. S. A. Heymans, E. J. DuivermanW. B. Geven, M. L. Duiverman, L. I. Geven, E. J. L. E. Vrijlandt, A. L. M. Mulder, A. Gerver, L. A. A. Kollee, L. Reijmers, R. Sonnemans, J. M. Wit, F. W. Dekker, N. Weisglas-Kuperus, M. G. Keijzer-Veen, A. J. van der Heijden, J. B. van Goudoever, M. M. van Weissenbruch, A. Cranendonk, H. A. Delemarre-van de Waal, L. de Groot, J. F. Samsom, L. S. de Vries, K. J. Rademaker, E. Moerman, M. Voogsgeerd, M. J. K. de Kleine, P. Andriessen, C. C. M. Dielissen-van Helvoirt, I. Mohamed, H. L. M. van Straaten, Dutch POPS-19 Collaborative Study Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Birth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA <32 weeks) differ from those with a very low birth weight (VLBW; BW <1,500 g) in postnatal growth up to their final height. Objective: To study whether neurodevelopmental and functional outcomes at the age of 19 years differ in VP and/or VLBW subjects. Methods: 705 19-year-old subjects from the Project on Preterm and Small-for-Gestational-Age Infants (POPS) cohort were classified as (1) VP+/VLBW+ (n = 354), (2) VP+/VLBW-(n = 144), or (3) VP-/VLBW+ (n = 207), and compared with regard to IQ as assessed with the Multicultural Capacity Test-intermediate level; neuromotor function using Touwen's examination of mild neurologic dysfunction; hearing loss; self-and parent-reported behavioral and emotional functioning; educational achievement and occupation; and self-assessed health using the Health Utilities Index and the London Handicap Scale. Results: VP+/VLBW-infants, on average, had 3.8-point higher IQ scores (95% confidence interval [CI] 0.57.1), a trend towards higher educational achievement, 3.3dB better hearing (95% CI 1.2-5.4), and less anxious behavior, attention problems, and internalizing behavior than to VP+/VLBW+ subjects. VP-/VLBW+ infants reported 1.8 increased odds (95% CI 1.2-2.6) of poor health compared to VP+/VLBW+ subjects. Conclusions: At the age of 19 years, subjects born VP+/VLBW+, VP+/VLBW-, and VP-/VLBW+ have different neurodevelopmental and functional outcomes, although effect sizes are small. Hence, the terms VP and VLBW are not interchangeable. We recommend, at least for industrialized countries, to base inclusion in future studies on preterm populations on GA instead of on BW. (c) 2018 The Author(s) Published by S. Karger AG, Basel

Original language	English
Pages (from-to)	310-319
Number of pages	10
Journal	Neonatology
Volume	115
Issue number	4
DOIs	https://doi.org/10.1159/000495133
Publication status	Published - 2019

Keywords

Prematurity
Low gestational age
Adolescents
IQ
Behavior
Health status
Neuromotor functioning
YOUNG-ADULTS BORN
GESTATIONAL-AGE INFANTS
CHILDREN BORN
PSYCHOPATHOLOGY
PROJECT
HEALTH
COHORT
LIFE

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Cite this

Hollanders, J. J., Schaefer, N., van der Pal, S. M., Oosterlaan, J., Rotteveel, J., Finken, M. J. J., Hille, E. T. M., de Groot, C. H., Kloosterboer-Boerrigter, H., den Ouden, A. L., Rijpstra, A., Verloove-Vanhorick, S. P., Vogelaar, J. A., Kok, J. H., Ilsen, A., van der Lans, M., Boelen-van der Loo, W. J. C., Lundqvist, T., Heymans, H. S. A., ... Dutch POPS-19 Collaborative Study Group (2019). Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight. Neonatology, 115(4), 310-319. https://doi.org/10.1159/000495133

@article{2560e1b271054415b614d1fa5174527c,

title = "Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight",

abstract = "Background: Birth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA <32 weeks) differ from those with a very low birth weight (VLBW; BW <1,500 g) in postnatal growth up to their final height. Objective: To study whether neurodevelopmental and functional outcomes at the age of 19 years differ in VP and/or VLBW subjects. Methods: 705 19-year-old subjects from the Project on Preterm and Small-for-Gestational-Age Infants (POPS) cohort were classified as (1) VP+/VLBW+ (n = 354), (2) VP+/VLBW-(n = 144), or (3) VP-/VLBW+ (n = 207), and compared with regard to IQ as assessed with the Multicultural Capacity Test-intermediate level; neuromotor function using Touwen's examination of mild neurologic dysfunction; hearing loss; self-and parent-reported behavioral and emotional functioning; educational achievement and occupation; and self-assessed health using the Health Utilities Index and the London Handicap Scale. Results: VP+/VLBW-infants, on average, had 3.8-point higher IQ scores (95% confidence interval [CI] 0.57.1), a trend towards higher educational achievement, 3.3dB better hearing (95% CI 1.2-5.4), and less anxious behavior, attention problems, and internalizing behavior than to VP+/VLBW+ subjects. VP-/VLBW+ infants reported 1.8 increased odds (95% CI 1.2-2.6) of poor health compared to VP+/VLBW+ subjects. Conclusions: At the age of 19 years, subjects born VP+/VLBW+, VP+/VLBW-, and VP-/VLBW+ have different neurodevelopmental and functional outcomes, although effect sizes are small. Hence, the terms VP and VLBW are not interchangeable. We recommend, at least for industrialized countries, to base inclusion in future studies on preterm populations on GA instead of on BW. (c) 2018 The Author(s) Published by S. Karger AG, Basel",

keywords = "Prematurity, Low gestational age, Adolescents, IQ, Behavior, Health status, Neuromotor functioning, YOUNG-ADULTS BORN, GESTATIONAL-AGE INFANTS, CHILDREN BORN, PSYCHOPATHOLOGY, PROJECT, HEALTH, COHORT, LIFE",

author = "Hollanders, {Jonneke J.} and Nina Schaefer and {van der Pal}, {Sylvia M.} and Jaap Oosterlaan and Joost Rotteveel and Finken, {M. J. J.} and Hille, {E. T. M.} and {de Groot}, {C. H.} and H. Kloosterboer-Boerrigter and {den Ouden}, {A. L.} and A. Rijpstra and Verloove-Vanhorick, {S. P.} and Vogelaar, {J. A.} and Kok, {J. H.} and A. Ilsen and {van der Lans}, M. and {Boelen-van der Loo}, {W. J. C.} and T. Lundqvist and Heymans, {H. S. A.} and Duiverman, {E. J.} and Geven, {W. B.} and Duiverman, {M. L.} and Geven, {L. I.} and Vrijlandt, {E. J. L. E.} and Mulder, {A. L. M.} and A. Gerver and Kollee, {L. A. A.} and L. Reijmers and R. Sonnemans and Wit, {J. M.} and Dekker, {F. W.} and N. Weisglas-Kuperus and Keijzer-Veen, {M. G.} and {van der Heijden}, {A. J.} and {van Goudoever}, {J. B.} and {van Weissenbruch}, {M. M.} and A. Cranendonk and {Delemarre-van de Waal}, {H. A.} and {de Groot}, L. and Samsom, {J. F.} and {de Vries}, {L. S.} and Rademaker, {K. J.} and E. Moerman and M. Voogsgeerd and {de Kleine}, {M. J. K.} and P. Andriessen and {Dielissen-van Helvoirt}, {C. C. M.} and I. Mohamed and {van Straaten}, {H. L. M.} and {Dutch POPS-19 Collaborative Study Group}",

note = "Funding Information: The authors did not receive funding for this particular article. The POPS-19 follow-up was supported by grants from the Netherlands Organisation for Health Research and Development (ZonMw), Edgar Doncker Foundation, Foundation for Public Health Fundraising Campaigns, Phelps Foundation, Swart-van Essen Foundation, Foundation for Childrens Welfare Stamps, TNO Prevention and Health, Netherlands Organisation for Scientific Research (NWO), Dutch Kidney Foundation, Sophia Foundation for Medical Research, Stichting Astmabestrijding, Royal Ef-fatha Guyot group. Publisher Copyright: {\textcopyright} 2019 The Author(s) Published by S. Karger AG, Basel.",

year = "2019",

doi = "10.1159/000495133",

language = "English",

volume = "115",

pages = "310--319",

journal = "Neonatology",

issn = "1661-7800",

publisher = "Karger",

number = "4",

}

Hollanders, JJ, Schaefer, N, van der Pal, SM, Oosterlaan, J, Rotteveel, J, Finken, MJJ, Hille, ETM, de Groot, CH, Kloosterboer-Boerrigter, H, den Ouden, AL, Rijpstra, A, Verloove-Vanhorick, SP, Vogelaar, JA, Kok, JH, Ilsen, A, van der Lans, M, Boelen-van der Loo, WJC, Lundqvist, T, Heymans, HSA, Duiverman, EJ, Geven, WB, Duiverman, ML, Geven, LI, Vrijlandt, EJLE, Mulder, ALM, Gerver, A, Kollee, LAA, Reijmers, L, Sonnemans, R, Wit, JM, Dekker, FW, Weisglas-Kuperus, N, Keijzer-Veen, MG, van der Heijden, AJ, van Goudoever, JB, van Weissenbruch, MM, Cranendonk, A, Delemarre-van de Waal, HA, de Groot, L, Samsom, JF, de Vries, LS, Rademaker, KJ, Moerman, E, Voogsgeerd, M, de Kleine, MJK, Andriessen, P, Dielissen-van Helvoirt, CCM, Mohamed, I, van Straaten, HLM & Dutch POPS-19 Collaborative Study Group 2019, 'Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight', Neonatology, vol. 115, no. 4, pp. 310-319. https://doi.org/10.1159/000495133

TY - JOUR

T1 - Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight

AU - Hollanders, Jonneke J.

AU - Schaefer, Nina

AU - van der Pal, Sylvia M.

AU - Oosterlaan, Jaap

AU - Rotteveel, Joost

AU - Finken, M. J. J.

AU - Hille, E. T. M.

AU - de Groot, C. H.

AU - Kloosterboer-Boerrigter, H.

AU - den Ouden, A. L.

AU - Rijpstra, A.

AU - Verloove-Vanhorick, S. P.

AU - Vogelaar, J. A.

AU - Kok, J. H.

AU - Ilsen, A.

AU - van der Lans, M.

AU - Boelen-van der Loo, W. J. C.

AU - Lundqvist, T.

AU - Heymans, H. S. A.

AU - Duiverman, E. J.

AU - Geven, W. B.

AU - Duiverman, M. L.

AU - Geven, L. I.

AU - Vrijlandt, E. J. L. E.

AU - Mulder, A. L. M.

AU - Gerver, A.

AU - Kollee, L. A. A.

AU - Reijmers, L.

AU - Sonnemans, R.

AU - Wit, J. M.

AU - Dekker, F. W.

AU - Weisglas-Kuperus, N.

AU - Keijzer-Veen, M. G.

AU - van der Heijden, A. J.

AU - van Goudoever, J. B.

AU - van Weissenbruch, M. M.

AU - Cranendonk, A.

AU - Delemarre-van de Waal, H. A.

AU - de Groot, L.

AU - Samsom, J. F.

AU - de Vries, L. S.

AU - Rademaker, K. J.

AU - Moerman, E.

AU - Voogsgeerd, M.

AU - de Kleine, M. J. K.

AU - Andriessen, P.

AU - Dielissen-van Helvoirt, C. C. M.

AU - Mohamed, I.

AU - van Straaten, H. L. M.

AU - Dutch POPS-19 Collaborative Study Group

N1 - Funding Information: The authors did not receive funding for this particular article. The POPS-19 follow-up was supported by grants from the Netherlands Organisation for Health Research and Development (ZonMw), Edgar Doncker Foundation, Foundation for Public Health Fundraising Campaigns, Phelps Foundation, Swart-van Essen Foundation, Foundation for Childrens Welfare Stamps, TNO Prevention and Health, Netherlands Organisation for Scientific Research (NWO), Dutch Kidney Foundation, Sophia Foundation for Medical Research, Stichting Astmabestrijding, Royal Ef-fatha Guyot group. Publisher Copyright: © 2019 The Author(s) Published by S. Karger AG, Basel.

PY - 2019

Y1 - 2019

N2 - Background: Birth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA <32 weeks) differ from those with a very low birth weight (VLBW; BW <1,500 g) in postnatal growth up to their final height. Objective: To study whether neurodevelopmental and functional outcomes at the age of 19 years differ in VP and/or VLBW subjects. Methods: 705 19-year-old subjects from the Project on Preterm and Small-for-Gestational-Age Infants (POPS) cohort were classified as (1) VP+/VLBW+ (n = 354), (2) VP+/VLBW-(n = 144), or (3) VP-/VLBW+ (n = 207), and compared with regard to IQ as assessed with the Multicultural Capacity Test-intermediate level; neuromotor function using Touwen's examination of mild neurologic dysfunction; hearing loss; self-and parent-reported behavioral and emotional functioning; educational achievement and occupation; and self-assessed health using the Health Utilities Index and the London Handicap Scale. Results: VP+/VLBW-infants, on average, had 3.8-point higher IQ scores (95% confidence interval [CI] 0.57.1), a trend towards higher educational achievement, 3.3dB better hearing (95% CI 1.2-5.4), and less anxious behavior, attention problems, and internalizing behavior than to VP+/VLBW+ subjects. VP-/VLBW+ infants reported 1.8 increased odds (95% CI 1.2-2.6) of poor health compared to VP+/VLBW+ subjects. Conclusions: At the age of 19 years, subjects born VP+/VLBW+, VP+/VLBW-, and VP-/VLBW+ have different neurodevelopmental and functional outcomes, although effect sizes are small. Hence, the terms VP and VLBW are not interchangeable. We recommend, at least for industrialized countries, to base inclusion in future studies on preterm populations on GA instead of on BW. (c) 2018 The Author(s) Published by S. Karger AG, Basel

AB - Background: Birth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA <32 weeks) differ from those with a very low birth weight (VLBW; BW <1,500 g) in postnatal growth up to their final height. Objective: To study whether neurodevelopmental and functional outcomes at the age of 19 years differ in VP and/or VLBW subjects. Methods: 705 19-year-old subjects from the Project on Preterm and Small-for-Gestational-Age Infants (POPS) cohort were classified as (1) VP+/VLBW+ (n = 354), (2) VP+/VLBW-(n = 144), or (3) VP-/VLBW+ (n = 207), and compared with regard to IQ as assessed with the Multicultural Capacity Test-intermediate level; neuromotor function using Touwen's examination of mild neurologic dysfunction; hearing loss; self-and parent-reported behavioral and emotional functioning; educational achievement and occupation; and self-assessed health using the Health Utilities Index and the London Handicap Scale. Results: VP+/VLBW-infants, on average, had 3.8-point higher IQ scores (95% confidence interval [CI] 0.57.1), a trend towards higher educational achievement, 3.3dB better hearing (95% CI 1.2-5.4), and less anxious behavior, attention problems, and internalizing behavior than to VP+/VLBW+ subjects. VP-/VLBW+ infants reported 1.8 increased odds (95% CI 1.2-2.6) of poor health compared to VP+/VLBW+ subjects. Conclusions: At the age of 19 years, subjects born VP+/VLBW+, VP+/VLBW-, and VP-/VLBW+ have different neurodevelopmental and functional outcomes, although effect sizes are small. Hence, the terms VP and VLBW are not interchangeable. We recommend, at least for industrialized countries, to base inclusion in future studies on preterm populations on GA instead of on BW. (c) 2018 The Author(s) Published by S. Karger AG, Basel

KW - Prematurity

KW - Low gestational age

KW - Adolescents

KW - IQ

KW - Behavior

KW - Health status

KW - Neuromotor functioning

KW - YOUNG-ADULTS BORN

KW - GESTATIONAL-AGE INFANTS

KW - CHILDREN BORN

KW - PSYCHOPATHOLOGY

KW - PROJECT

KW - HEALTH

KW - COHORT

KW - LIFE

U2 - 10.1159/000495133

DO - 10.1159/000495133

M3 - Article

C2 - 30836372

SN - 1661-7800

VL - 115

SP - 310

EP - 319

JO - Neonatology

JF - Neonatology

IS - 4

ER -