Long-Term Impact of Endometrial Cancer Diagnosis and Treatment on Health-Related Quality of Life and Cancer Survivorship: Results From the Randomized PORTEC-2 Trial

Stephanie M. de Boer*, Remi A. Nout, Ina M. Jurgenliemk-Schulz, Jan J. Jobsen, Ludy C. H. W. Lutgens, Elzbieta M. van der Steen-Banasik, Jan Willem M. Mens, Annerie Slot, Marika C. Stenfert Kroese, Simone Oerlemans, Hein Putter, Karen W. Verhoeven-Adema, Hans W. Nijman, Carien L. Creutzberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Web of Science)

Abstract

Purpose: To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among PORTEC-2 trial patients, evaluate long-term bowel and bladder symptoms, and assess the impact of cancer on these endometrial cancer (EC) survivors. Patients and Methods: In the PORTEC-2 trial, 427 patients with stage I high-intermediate-risk EC were randomly allocated to EBRT or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and bladder symptoms; the Impact of Cancer Questionnaire; and 14 questions on comorbidities, walking aids, and incontinence pads. Analysis was done using linear mixed models for subscales and (ordinal) logistic regression with random effects for single items. A two-sided P value
Original languageEnglish
Pages (from-to)797-809
JournalInternational Journal of Radiation Oncology Biology Physics
Volume93
Issue number4
DOIs
Publication statusPublished - 15 Nov 2015

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