Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen Lopez-Iglesias, Florijn Dekkers, Onur Basak, Johan van Es, Susana M. Chuva de Sousa Lopes, Harry Begthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne Rios, Peter J. Peters, Ype P. de Jong, Hans Clevers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1591-1606.e19
Number of pages36
JournalCell
Volume175
Issue number6
DOIs
Publication statusPublished - 29 Nov 2018

Keywords

  • LIVER STEM-CELLS
  • IN-VITRO EXPANSION
  • MATURE HEPATOCYTES
  • SOMATIC MUTATIONS
  • PROGENITOR CELLS
  • ADULT LIVER
  • CULTURE
  • CHOLANGIOCYTES
  • HOMEOSTASIS
  • FIBROBLASTS

Cite this

Hu, H., Gehart, H., Artegiani, B., Lopez-Iglesias, C., Dekkers, F., Basak, O., van Es, J., Lopes, S. M. C. D. S., Begthel, H., Korving, J., van den Born, M., Zou, C., Quirk, C., Chiriboga, L., Rice, C. M., Ma, S., Rios, A., Peters, P. J., de Jong, Y. P., & Clevers, H. (2018). Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids. Cell, 175(6), 1591-1606.e19. https://doi.org/10.1016/j.cell.2018.11.013