Long-term expanding human airway organoids for disease modeling

Norman Sachs, Angelos Papaspyropoulos, Domenique D. Zomer-van Ommen, Inha Heo, Lena Bottinger, Dymph Klay, Fleur Weeber, Guizela Huelsz-Prince, Nino Iakobachvili, Gimano D. Amatngalim, Joep de Ligt, Arne van Hoeck, Natalie Proost, Marco C. Viveen, Anna Lyubimova, Luc Teeven, Sepideh Derakhshan, Jeroen Korving, Harry Begthel, Johanna F. DekkersKuldeep Kumawat, Emilio Ramos, Matthijs F. M. van Oosterhout, G. Johan Offerhaus, Dominique J. Wiener, Eduardo P. Olimpio, Krijn K. Dijkstra, Egbert F. Smit, Maarten van der Linden, Sridevi Jaksani, Marieke van de Ven, Jos Jonkers, Anne C. Rios, Emile E. Voest, Coline H. M. van Moorsel, Cornelis K. van der Ent, Edwin Cuppen, Alexander van Oudenaarden, Frank E. Coenjaerts, Linde Meyaard, Louis J. Bont, Peter J. Peters, Sander J. Tans, Jeroen S. van Zon, Sylvia F. Boj, Robert G. Vries, Jeffrey M. Beekman, Hans Clevers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number100300
Number of pages20
JournalThe Embo Journal
Volume38
Issue number4
DOIs
Publication statusPublished - 15 Feb 2019

Keywords

  • 3D culture
  • airway organoids
  • cystic fibrosis
  • lung cancer
  • respiratory syncytial virus
  • PLURIPOTENT STEM-CELLS
  • CYSTIC-FIBROSIS
  • CHLORIDE CHANNEL
  • BASAL-CELLS
  • EPITHELIUM
  • REGENERATION
  • TARGET
  • GENERATION
  • DERIVATION
  • INHIBITION

Cite this

Sachs, N., Papaspyropoulos, A., Zomer-van Ommen, D. D., Heo, I., Bottinger, L., Klay, D., Weeber, F., Huelsz-Prince, G., Iakobachvili, N., Amatngalim, G. D., de Ligt, J., van Hoeck, A., Proost, N., Viveen, M. C., Lyubimova, A., Teeven, L., Derakhshan, S., Korving, J., Begthel, H., ... Clevers, H. (2019). Long-term expanding human airway organoids for disease modeling. The Embo Journal, 38(4), [100300]. https://doi.org/10.15252/embj.2018100300