Long-term effects of growth hormone treatment on growth and puberty in patients with chronic renal insufficiency

A.C. Hokken-Koelega*, P. Mulder, R. de Jong, M. Lilien, R.A.M.G. Donckerwolcke, J. Groothof

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Several prospective trials have shown that recombinant human growth hormone (GH) accelerates growth significantly during the first years of therapy, but the effects of long-term GH therapy with regard to long-term growth response and safety have not yet been established. Forty-five Dutch prepubertal children [28 boys, 17 girls, mean (SD) age 7.8 (3.4) years] with chronic renal insufficiency (CRI) and severe growth retardation started GH therapy between 1988 and 1991 within one of the randomized Dutch trials. Long-term GH therapy, in this study a maximum of 8 years, resulted in a sustained and significant improvement of height standard deviation score (SDS) compared with baseline values (P
Original languageEnglish
Pages (from-to)701-706
Number of pages6
JournalPediatric Nephrology
Issue number7
Publication statusPublished - 1 Jan 2000

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