TY - JOUR
T1 - Long-term effects of growth hormone treatment on growth and puberty in patients with chronic renal insufficiency
AU - Hokken-Koelega, A.C.
AU - Mulder, P.
AU - de Jong, R.
AU - Lilien, M.
AU - Donckerwolcke, R.A.M.G.
AU - Groothof, J.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Several prospective trials have shown that recombinant human growth hormone (GH) accelerates growth significantly during the first years of therapy, but the effects of long-term GH therapy with regard to long-term growth response and safety have not yet been established. Forty-five Dutch prepubertal children [28 boys, 17 girls, mean (SD) age 7.8 (3.4) years] with chronic renal insufficiency (CRI) and severe growth retardation started GH therapy between 1988 and 1991 within one of the randomized Dutch trials. Long-term GH therapy, in this study a maximum of 8 years, resulted in a sustained and significant improvement of height standard deviation score (SDS) compared with baseline values (P
AB - Several prospective trials have shown that recombinant human growth hormone (GH) accelerates growth significantly during the first years of therapy, but the effects of long-term GH therapy with regard to long-term growth response and safety have not yet been established. Forty-five Dutch prepubertal children [28 boys, 17 girls, mean (SD) age 7.8 (3.4) years] with chronic renal insufficiency (CRI) and severe growth retardation started GH therapy between 1988 and 1991 within one of the randomized Dutch trials. Long-term GH therapy, in this study a maximum of 8 years, resulted in a sustained and significant improvement of height standard deviation score (SDS) compared with baseline values (P
U2 - 10.1007/s004670000340
DO - 10.1007/s004670000340
M3 - Article
C2 - 10912546
SN - 0931-041X
VL - 14
SP - 701
EP - 706
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 7
ER -