Background: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. Methods: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. Results: Sodium intake increased RCC risk (P-trend = 0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction = 0.02). Conclusion: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.
Deckers, I. A. G., van den Brandt, P. A., van Engeland, M., Soetekouw, P. M. M. B., Baldewijns, M. M. L. L., Goldbohm, R. A., & Schouten, L. J. (2014). Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer. British Journal of Cancer, 110, 797-801. https://doi.org/10.1038/bjc.2013.771