Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer

I.A.G. Deckers; P.A. van den Brandt; M. van Engeland; P.M.M.B. Soetekouw; M.M.L.L. Baldewijns; R.A. Goldbohm; L.J. Schouten

doi:10.1038/bjc.2013.771

Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer

I.A.G. Deckers^*, P.A. van den Brandt, M. van Engeland, P.M.M.B. Soetekouw, M.M.L.L. Baldewijns, R.A. Goldbohm, L.J. Schouten

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. Methods: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. Results: Sodium intake increased RCC risk (P-trend = 0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction = 0.02). Conclusion: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.

Original language	English
Pages (from-to)	797-801
Journal	British Journal of Cancer
Volume	110
DOIs	https://doi.org/10.1038/bjc.2013.771
Publication status	Published - 1 Jan 2014

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10.1038/bjc.2013.771Licence: CC BY-NC-SA

Cite this

Deckers, I. A. G., van den Brandt, P. A., van Engeland, M., Soetekouw, P. M. M. B., Baldewijns, M. M. L. L., Goldbohm, R. A., & Schouten, L. J. (2014). Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer. British Journal of Cancer, 110, 797-801. https://doi.org/10.1038/bjc.2013.771

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title = "Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer",

abstract = "Background: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. Methods: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. Results: Sodium intake increased RCC risk (P-trend = 0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction = 0.02). Conclusion: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.",

author = "I.A.G. Deckers and {van den Brandt}, P.A. and {van Engeland}, M. and P.M.M.B. Soetekouw and M.M.L.L. Baldewijns and R.A. Goldbohm and L.J. Schouten",

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Deckers, IAG, van den Brandt, PA , van Engeland, M, Soetekouw, PMMB, Baldewijns, MMLL, Goldbohm, RA & Schouten, LJ 2014, 'Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer', British Journal of Cancer, vol. 110, pp. 797-801. https://doi.org/10.1038/bjc.2013.771

Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer. / Deckers, I.A.G.; van den Brandt, P.A.; van Engeland, M. et al.
In: British Journal of Cancer, Vol. 110, 01.01.2014, p. 797-801.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer

AU - Deckers, I.A.G.

AU - van den Brandt, P.A.

AU - van Engeland, M.

AU - Soetekouw, P.M.M.B.

AU - Baldewijns, M.M.L.L.

AU - Goldbohm, R.A.

AU - Schouten, L.J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. Methods: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. Results: Sodium intake increased RCC risk (P-trend = 0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction = 0.02). Conclusion: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.

AB - Background: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. Methods: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. Results: Sodium intake increased RCC risk (P-trend = 0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction = 0.02). Conclusion: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.

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