TY - JOUR
T1 - Long sleep duration is associated with lower cognitive function among middle-age adults - the Doetinchem Cohort Study
AU - van Oostrom, Sandra H.
AU - Nooyens, Astrid C. J.
AU - van Boxtel, Martin P. J.
AU - Verschuren, W. M. Monique
PY - 2018/1
Y1 - 2018/1
N2 - Objectives: In older adults, both short and long sleep duration are associated with lower cognitive function, suggesting an inverted U-shaped association between sleep duration and cognitive outcomes. This study examined whether sleep duration is associated with (changes in) cognitive function in a middle-aged population. Methods: In the Doetinchem Cohort Study, the cognitive function of 2970 men and women aged 41-75 years at baseline (1995-2007) was examined 2-3 times, with 5-year time intervals. Global cognitive function and the domains memory, information processing speed, and cognitive flexibility were assessed. In multivariable linear regression models, (change in) self-reported sleep duration was studied in association with the level and change in cognitive function. In a subsample of the population (n = 2587), the association of sleep duration and feeling rested with cognitive function was studied. Results: Sleep duration of 9 h and more was statistically significantly associated with lower global cognitive function (p <0.01), memory (p = 0.02), and flexibility (p = 0.03), compared to a sleep duration of 7 or 8 h. Among adults feeling frequently not well rested, both short and long sleep duration were associated with a lower speed of cognitive function. An inverted U-shaped association between sleep duration and cognitive function was observed for speed, flexibility, and global cognitive function. Sleep duration was not associated with change in cognitive function. Conclusions: Middle-age adults with long sleep duration had a lower cognitive function.
AB - Objectives: In older adults, both short and long sleep duration are associated with lower cognitive function, suggesting an inverted U-shaped association between sleep duration and cognitive outcomes. This study examined whether sleep duration is associated with (changes in) cognitive function in a middle-aged population. Methods: In the Doetinchem Cohort Study, the cognitive function of 2970 men and women aged 41-75 years at baseline (1995-2007) was examined 2-3 times, with 5-year time intervals. Global cognitive function and the domains memory, information processing speed, and cognitive flexibility were assessed. In multivariable linear regression models, (change in) self-reported sleep duration was studied in association with the level and change in cognitive function. In a subsample of the population (n = 2587), the association of sleep duration and feeling rested with cognitive function was studied. Results: Sleep duration of 9 h and more was statistically significantly associated with lower global cognitive function (p <0.01), memory (p = 0.02), and flexibility (p = 0.03), compared to a sleep duration of 7 or 8 h. Among adults feeling frequently not well rested, both short and long sleep duration were associated with a lower speed of cognitive function. An inverted U-shaped association between sleep duration and cognitive function was observed for speed, flexibility, and global cognitive function. Sleep duration was not associated with change in cognitive function. Conclusions: Middle-age adults with long sleep duration had a lower cognitive function.
KW - Sleep duration
KW - Cognitive function
KW - Cohort study
KW - Middle age
U2 - 10.1016/j.sleep.2017.07.029
DO - 10.1016/j.sleep.2017.07.029
M3 - Article
C2 - 29425581
SN - 1389-9457
VL - 41
SP - 78
EP - 85
JO - Sleep Medicine
JF - Sleep Medicine
ER -