Long non-coding RNAs in the failing heart and vasculature

Steffie Hermans-Beijnsberger, Marc van Bilsen, Blanche Schroen

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Following completion of the human genome, it became evident that the majority of our DNA is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA. Deciphering the function of these ncRNAs, including both small- and long ncRNAs (lncRNAs), is an emerging field of research. LncRNAs have been associated with many disorders and a number have been identified as key regulators in the development and progression of disease, including cardiovascular disease (CVD). CVD causes millions of deaths worldwide, annually. Risk factors include coronary artery disease, high blood pressure and ageing. In this review, we will focus on the roles of lncRNAs in the cellular and molecular processes that underlie the development of CVD: cardiomyocyte hypertrophy, fibrosis, inflammation, vascular disease and ageing. Finally, we discuss the biomarker and therapeutic potential of lncRNAs.

Original languageEnglish
Pages (from-to)118-130
Number of pages13
JournalNon-coding RNA research
Volume3
Issue number3
DOIs
Publication statusPublished - Sep 2018

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