Local recurrences in western low rectal cancer patients treated with or without lateral lymph node dissection after neoadjuvant (chemo) radiotherapy: An international multi-centre comparative study

H.M. Kroon*, S. Malakorn, N.N. Dudi-Venkata, S. Bedrikovetski, J.L. Liu, T. Kenyon-Smith, B.K. Bednarski, A. Ogura, C.J.H. van de Velde, H.J.T. Rutten, G.L. Beets, M.L. Thomas, M. Kusters, G.R.J. Chang, T. Sammour

*Corresponding author for this work

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Abstract

Background: In the West, low rectal cancer patients with abnormal lateral lymph nodes (LLNs) are commonly treated with neoadjuvant (chemo)radiotherapy (nCRT) followed by total mesorectal excision (TME). Additionally, some perform a lateral lymph node dissection (LLND). To date, no comparative data (nCRT vs. nCRT + LLND) are available in Western patients. Methods: An international multi-centre cohort study was conducted at six centres from the Netherlands, US and Australia. Patients with low rectal cancers from the Netherlands and Australia with abnormal LLNs (>5 mm short-axis in the obturator, internal iliac, external iliac and/or common iliac basin) who underwent nCRT and TME (LLND-group) were compared to similarly staged patients from the US who underwent a LLND in addition to nCRT and TME (LLND + group). Results: LLND + patients (n = 44) were younger with higher ASA-classifications and ypN-stages compared to LLND-patients (n = 115). LLND + patients had larger median LLNs short-axes and received more adjuvant chemotherapy (100 vs. 30%; p < 0.0001). Between groups, the local recurrence rate (LRR) was 3% for LLND + vs. 11% for LLND-(p = 0.13). Disease-free survival (DFS, p = 0.94) and overall survival (OS, p = 0.42) were similar. On multivariable analysis, LLND was an independent sig-nificant factor for local recurrences (p = 0.01). Sub-analysis of patients who underwent long-course nCRT and had adjuvant chemotherapy (LLND-n = 30, LLND + n = 44) demonstrated a lower LRR for LLND + patients (3% vs. 16% for LLND-; p = 0.04). DFS (p = 0.10) and OS (p = 0.11) were similar between groups. Conclusion: A LLND in addition to nCRT may improve loco-regional control in Western patients with low rectal cancer and abnormal LLNs. Larger studies in Western patients are required to evaluate its contribution. (c) 2021 Elsevier Ltd, BASO -The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Original languageEnglish
Pages (from-to)2441-2449
Number of pages9
JournalEuropean Journal of Surgical Oncology
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Sept 2021

Keywords

  • Low rectal cancer
  • Locally advanced rectal cancer
  • Neoadjuvant (chemo)radiotherapy
  • Lateral lymph nodes
  • Lateral lymph node dissection
  • JAPANESE SOCIETY
  • CHEMORADIOTHERAPY
  • CHEMORADIATION
  • GUIDELINES
  • RESECTION
  • EXCISION
  • OUTCOMES
  • COLON

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