Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Pawel Kuklik; Benjamin Schaeffer; Boris A. Hoffmann; Anand N. Ganesan; Doreen Schreiber; Julia M. Moser; Ruken O. Akbulak; Arian Sultan; Daniel Steven; Bart Maesen; Ulrich Schotten; Christian Meyer; Stephan Willems

doi:10.1371/journal.pone.0164236

Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Pawel Kuklik^*, Benjamin Schaeffer, Boris A. Hoffmann, Anand N. Ganesan, Doreen Schreiber, Julia M. Moser, Ruken O. Akbulak, Arian Sultan, Daniel Steven, Bart Maesen, Ulrich Schotten, Christian Meyer, Stephan Willems

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R-2 = 0.68, p

Original language	English
Article number	e0164236
Journal	PLOS ONE
Volume	11
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0164236
Publication status	Published - 25 Oct 2016

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10.1371/journal.pone.0164236Licence: CC BY

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Kuklik, P., Schaeffer, B., Hoffmann, B. A., Ganesan, A. N., Schreiber, D., Moser, J. M., Akbulak, R. O., Sultan, A., Steven, D., Maesen, B., Schotten, U., Meyer, C., & Willems, S. (2016). Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results. PLOS ONE, 11(10), Article e0164236. https://doi.org/10.1371/journal.pone.0164236

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title = "Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results",

abstract = "Background Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R-2 = 0.68, p",

author = "Pawel Kuklik and Benjamin Schaeffer and Hoffmann, \{Boris A.\} and Ganesan, \{Anand N.\} and Doreen Schreiber and Moser, \{Julia M.\} and Akbulak, \{Ruken O.\} and Arian Sultan and Daniel Steven and Bart Maesen and Ulrich Schotten and Christian Meyer and Stephan Willems",

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Kuklik, P, Schaeffer, B, Hoffmann, BA, Ganesan, AN, Schreiber, D, Moser, JM, Akbulak, RO, Sultan, A, Steven, D, Maesen, B , Schotten, U, Meyer, C & Willems, S 2016, 'Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results', PLOS ONE, vol. 11, no. 10, e0164236. https://doi.org/10.1371/journal.pone.0164236

TY - JOUR

T1 - Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

AU - Kuklik, Pawel

AU - Schaeffer, Benjamin

AU - Hoffmann, Boris A.

AU - Ganesan, Anand N.

AU - Schreiber, Doreen

AU - Moser, Julia M.

AU - Akbulak, Ruken O.

AU - Sultan, Arian

AU - Steven, Daniel

AU - Maesen, Bart

AU - Schotten, Ulrich

AU - Meyer, Christian

AU - Willems, Stephan

PY - 2016/10/25

Y1 - 2016/10/25

N2 - Background Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R-2 = 0.68, p

AB - Background Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R-2 = 0.68, p

U2 - 10.1371/journal.pone.0164236

DO - 10.1371/journal.pone.0164236

M3 - Article

C2 - 27780243

SN - 1932-6203

VL - 11

JO - PLOS ONE

JF - PLOS ONE

IS - 10

M1 - e0164236

ER -

Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

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