Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Pawel Kuklik*, Benjamin Schaeffer, Boris A. Hoffmann, Anand N. Ganesan, Doreen Schreiber, Julia M. Moser, Ruken O. Akbulak, Arian Sultan, Daniel Steven, Bart Maesen, Ulrich Schotten, Christian Meyer, Stephan Willems

*Corresponding author for this work

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Abstract

Background Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R-2 = 0.68, p
Original languageEnglish
Article numbere0164236
JournalPLOS ONE
Volume11
Issue number10
DOIs
Publication statusPublished - 25 Oct 2016

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