Loss of SERCA function contributes to reduced contractility, Ca2+ overload and arrhythmias in the diseased heart. A long non-coding RNA (ZFAS1) upregulated in cardiac disease is reported to directly inhibit SERCA function. The implications for cardiac disease and the wider roles of SERCA are discussed.
- Heart Diseases/metabolism
- Models, Biological
- RNA, Long Noncoding/genetics
- Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism