Lnc'ing Ca2+, SERCA and cardiac disease

Tim Vervliet, Emma L Robinson, H Llewelyn Roderick*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Loss of SERCA function contributes to reduced contractility, Ca2+ overload and arrhythmias in the diseased heart. A long non-coding RNA (ZFAS1) upregulated in cardiac disease is reported to directly inhibit SERCA function. The implications for cardiac disease and the wider roles of SERCA are discussed.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalCell Calcium
Publication statusPublished - Jun 2018
Externally publishedYes


  • Animals
  • Calcium/metabolism
  • Heart Diseases/metabolism
  • Humans
  • Models, Biological
  • RNA, Long Noncoding/genetics
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism

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