Lnc'ing Ca2+, SERCA and cardiac disease

Tim Vervliet; Emma L Robinson; H Llewelyn Roderick

doi:10.1016/j.ceca.2018.05.005

Lnc'ing Ca2+, SERCA and cardiac disease

Tim Vervliet, Emma L Robinson, H Llewelyn Roderick^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Loss of SERCA function contributes to reduced contractility, Ca2+ overload and arrhythmias in the diseased heart. A long non-coding RNA (ZFAS1) upregulated in cardiac disease is reported to directly inhibit SERCA function. The implications for cardiac disease and the wider roles of SERCA are discussed.

Original language	English
Pages (from-to)	132-134
Number of pages	3
Journal	Cell Calcium
Volume	72
DOIs	https://doi.org/10.1016/j.ceca.2018.05.005
Publication status	Published - Jun 2018
Externally published	Yes

Keywords

Animals
Calcium/metabolism
Heart Diseases/metabolism
Humans
Models, Biological
RNA, Long Noncoding/genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism

Access to Document

10.1016/j.ceca.2018.05.005

Cite this

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title = "Lnc'ing Ca2+, SERCA and cardiac disease",

abstract = "Loss of SERCA function contributes to reduced contractility, Ca2+ overload and arrhythmias in the diseased heart. A long non-coding RNA (ZFAS1) upregulated in cardiac disease is reported to directly inhibit SERCA function. The implications for cardiac disease and the wider roles of SERCA are discussed.",

keywords = "Animals, Calcium/metabolism, Heart Diseases/metabolism, Humans, Models, Biological, RNA, Long Noncoding/genetics, Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism",

author = "Tim Vervliet and Robinson, {Emma L} and Roderick, {H Llewelyn}",

year = "2018",

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AU - Roderick, H Llewelyn

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KW - Animals

KW - Calcium/metabolism

KW - Heart Diseases/metabolism

KW - Humans

KW - Models, Biological

KW - RNA, Long Noncoding/genetics

KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism

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