Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort

Remon Korenblik; Jan Heil; Jens Smits; Sinead James; Bram Olij; Wolf O Bechstein; Marc H A Bemelmans; Christoph A Binkert; Stefan Breitenstein; Michael Williams; Olivier Detry; Maxime J L Dewulf; Alexandra Dili; Lukasz F Grochola; Jon Grote; Daniel Heise; Jennifer A Kalil; Peter Metrakos; Ulf P Neumann; Sam G Pappas; Francesca Pennetta; Andreas A Schnitzbauer; Jordan C Tasse; Bjorn Winkens; Steven W M Olde Damink; Christiaan van der Leij; Erik Schadde; Ronald M van Dam; DRAGON Trials Collaborative

doi:10.1093/bjs/znae087

Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort

Remon Korenblik^*, Jan Heil, Jens Smits, Sinead James, Bram Olij, Wolf O Bechstein, Marc H A Bemelmans, Christoph A Binkert, Stefan Breitenstein, Michael Williams, Olivier Detry, Maxime J L Dewulf, Alexandra Dili, Lukasz F Grochola, Jon Grote, Daniel Heise, Jennifer A Kalil, Peter Metrakos, Ulf P Neumann, Sam G PappasFrancesca Pennetta, Andreas A Schnitzbauer, Jordan C Tasse, Bjorn Winkens, Steven W M Olde Damink, Christiaan van der Leij, Erik Schadde, Ronald M van Dam, DRAGON Trials Collaborative

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The purpose of this study was to compare 3-year overall survival after simultaneous portal (PVE) and hepatic vein (HVE) embolization versus PVE alone in patients undergoing liver resection for primary and secondary cancers of the liver. METHODS: In this multicentre retrospective study, all DRAGON 0 centres provided 3-year follow-up data for all patients who had PVE/HVE or PVE, and were included in DRAGON 0 between 2016 and 2019. Kaplan-Meier analysis was undertaken to assess 3-year overall and recurrence/progression-free survival. Factors affecting survival were evaluated using univariable and multivariable Cox regression analyses. RESULTS: In total, 199 patients were included from 7 centres, of whom 39 underwent PVE/HVE and 160 PVE alone. Groups differed in median age (P = 0.008). As reported previously, PVE/HVE resulted in a significantly higher resection rate than PVE alone (92 versus 68%; P = 0.007). Three-year overall survival was significantly higher in the PVE/HVE group (median survival not reached after 36 months versus 20 months after PVE; P = 0.004). Univariable and multivariable analyses identified PVE/HVE as an independent predictor of survival (univariable HR 0.46, 95% c.i. 0.27 to 0.76; P = 0.003). CONCLUSION: Overall survival after PVE/HVE is substantially longer than that after PVE alone in patients with primary and secondary liver tumours.

Original language	English
Article number	znae087
Number of pages	9
Journal	British Journal of Surgery
Volume	111
Issue number	4
DOIs	https://doi.org/10.1093/bjs/znae087
Publication status	Published - 3 Apr 2024

Keywords

Humans
Portal Vein
Male
Female
Liver Neoplasms/therapy mortality surgery
Retrospective Studies
Embolization, Therapeutic/methods
Middle Aged
Liver Regeneration/physiology
Aged
Hepatic Veins
Hepatectomy/methods
Survival Rate
Survival Analysis
Adult

Access to Document

10.1093/bjs/znae087Licence: CC BY-NC

Cite this

Korenblik, R., Heil, J., Smits, J., James, S., Olij, B., Bechstein, W. O., Bemelmans, M. H. A., Binkert, C. A., Breitenstein, S., Williams, M., Detry, O., Dewulf, M. J. L., Dili, A., Grochola, L. F., Grote, J., Heise, D., Kalil, J. A., Metrakos, P., Neumann, U. P., ... DRAGON Trials Collaborative (2024). Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort. British Journal of Surgery, 111(4), Article znae087. https://doi.org/10.1093/bjs/znae087

@article{2a8dfa041f9c45dbb2f79327b4ddf484,

title = "Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort",

abstract = "BACKGROUND: The purpose of this study was to compare 3-year overall survival after simultaneous portal (PVE) and hepatic vein (HVE) embolization versus PVE alone in patients undergoing liver resection for primary and secondary cancers of the liver. METHODS: In this multicentre retrospective study, all DRAGON 0 centres provided 3-year follow-up data for all patients who had PVE/HVE or PVE, and were included in DRAGON 0 between 2016 and 2019. Kaplan-Meier analysis was undertaken to assess 3-year overall and recurrence/progression-free survival. Factors affecting survival were evaluated using univariable and multivariable Cox regression analyses. RESULTS: In total, 199 patients were included from 7 centres, of whom 39 underwent PVE/HVE and 160 PVE alone. Groups differed in median age (P = 0.008). As reported previously, PVE/HVE resulted in a significantly higher resection rate than PVE alone (92 versus 68%; P = 0.007). Three-year overall survival was significantly higher in the PVE/HVE group (median survival not reached after 36 months versus 20 months after PVE; P = 0.004). Univariable and multivariable analyses identified PVE/HVE as an independent predictor of survival (univariable HR 0.46, 95% c.i. 0.27 to 0.76; P = 0.003). CONCLUSION: Overall survival after PVE/HVE is substantially longer than that after PVE alone in patients with primary and secondary liver tumours.",

keywords = "Humans, Portal Vein, Male, Female, Liver Neoplasms/therapy mortality surgery, Retrospective Studies, Embolization, Therapeutic/methods, Middle Aged, Liver Regeneration/physiology, Aged, Hepatic Veins, Hepatectomy/methods, Survival Rate, Survival Analysis, Adult",

author = "Remon Korenblik and Jan Heil and Jens Smits and Sinead James and Bram Olij and Bechstein, {Wolf O} and Bemelmans, {Marc H A} and Binkert, {Christoph A} and Stefan Breitenstein and Michael Williams and Olivier Detry and Dewulf, {Maxime J L} and Alexandra Dili and Grochola, {Lukasz F} and Jon Grote and Daniel Heise and Kalil, {Jennifer A} and Peter Metrakos and Neumann, {Ulf P} and Pappas, {Sam G} and Francesca Pennetta and Schnitzbauer, {Andreas A} and Tasse, {Jordan C} and Bjorn Winkens and {Olde Damink}, {Steven W M} and {van der Leij}, Christiaan and Erik Schadde and {van Dam}, {Ronald M} and {DRAGON Trials Collaborative}",

year = "2024",

month = apr,

day = "3",

doi = "10.1093/bjs/znae087",

language = "English",

volume = "111",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "Oxford University Press",

number = "4",

}

Korenblik, R, Heil, J, Smits, J, James, S , Olij, B, Bechstein, WO, Bemelmans, MHA, Binkert, CA, Breitenstein, S, Williams, M, Detry, O, Dewulf, MJL, Dili, A, Grochola, LF, Grote, J, Heise, D, Kalil, JA, Metrakos, P, Neumann, UP, Pappas, SG, Pennetta, F, Schnitzbauer, AA, Tasse, JC, Winkens, B , Olde Damink, SWM , van der Leij, C, Schadde, E, van Dam, RM & DRAGON Trials Collaborative 2024, 'Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort', British Journal of Surgery, vol. 111, no. 4, znae087. https://doi.org/10.1093/bjs/znae087

Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort. / Korenblik, Remon; Heil, Jan; Smits, Jens et al.
In: British Journal of Surgery, Vol. 111, No. 4, znae087, 03.04.2024.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone

T2 - mid-term survival analysis of the multicentre DRAGON 0 cohort

AU - Korenblik, Remon

AU - Heil, Jan

AU - Smits, Jens

AU - James, Sinead

AU - Olij, Bram

AU - Bechstein, Wolf O

AU - Bemelmans, Marc H A

AU - Binkert, Christoph A

AU - Breitenstein, Stefan

AU - Williams, Michael

AU - Detry, Olivier

AU - Dewulf, Maxime J L

AU - Dili, Alexandra

AU - Grochola, Lukasz F

AU - Grote, Jon

AU - Heise, Daniel

AU - Kalil, Jennifer A

AU - Metrakos, Peter

AU - Neumann, Ulf P

AU - Pappas, Sam G

AU - Pennetta, Francesca

AU - Schnitzbauer, Andreas A

AU - Tasse, Jordan C

AU - Winkens, Bjorn

AU - Olde Damink, Steven W M

AU - van der Leij, Christiaan

AU - Schadde, Erik

AU - van Dam, Ronald M

AU - DRAGON Trials Collaborative

PY - 2024/4/3

Y1 - 2024/4/3

N2 - BACKGROUND: The purpose of this study was to compare 3-year overall survival after simultaneous portal (PVE) and hepatic vein (HVE) embolization versus PVE alone in patients undergoing liver resection for primary and secondary cancers of the liver. METHODS: In this multicentre retrospective study, all DRAGON 0 centres provided 3-year follow-up data for all patients who had PVE/HVE or PVE, and were included in DRAGON 0 between 2016 and 2019. Kaplan-Meier analysis was undertaken to assess 3-year overall and recurrence/progression-free survival. Factors affecting survival were evaluated using univariable and multivariable Cox regression analyses. RESULTS: In total, 199 patients were included from 7 centres, of whom 39 underwent PVE/HVE and 160 PVE alone. Groups differed in median age (P = 0.008). As reported previously, PVE/HVE resulted in a significantly higher resection rate than PVE alone (92 versus 68%; P = 0.007). Three-year overall survival was significantly higher in the PVE/HVE group (median survival not reached after 36 months versus 20 months after PVE; P = 0.004). Univariable and multivariable analyses identified PVE/HVE as an independent predictor of survival (univariable HR 0.46, 95% c.i. 0.27 to 0.76; P = 0.003). CONCLUSION: Overall survival after PVE/HVE is substantially longer than that after PVE alone in patients with primary and secondary liver tumours.

AB - BACKGROUND: The purpose of this study was to compare 3-year overall survival after simultaneous portal (PVE) and hepatic vein (HVE) embolization versus PVE alone in patients undergoing liver resection for primary and secondary cancers of the liver. METHODS: In this multicentre retrospective study, all DRAGON 0 centres provided 3-year follow-up data for all patients who had PVE/HVE or PVE, and were included in DRAGON 0 between 2016 and 2019. Kaplan-Meier analysis was undertaken to assess 3-year overall and recurrence/progression-free survival. Factors affecting survival were evaluated using univariable and multivariable Cox regression analyses. RESULTS: In total, 199 patients were included from 7 centres, of whom 39 underwent PVE/HVE and 160 PVE alone. Groups differed in median age (P = 0.008). As reported previously, PVE/HVE resulted in a significantly higher resection rate than PVE alone (92 versus 68%; P = 0.007). Three-year overall survival was significantly higher in the PVE/HVE group (median survival not reached after 36 months versus 20 months after PVE; P = 0.004). Univariable and multivariable analyses identified PVE/HVE as an independent predictor of survival (univariable HR 0.46, 95% c.i. 0.27 to 0.76; P = 0.003). CONCLUSION: Overall survival after PVE/HVE is substantially longer than that after PVE alone in patients with primary and secondary liver tumours.

KW - Humans

KW - Portal Vein

KW - Male

KW - Female

KW - Liver Neoplasms/therapy mortality surgery

KW - Retrospective Studies

KW - Embolization, Therapeutic/methods

KW - Middle Aged

KW - Liver Regeneration/physiology

KW - Aged

KW - Hepatic Veins

KW - Hepatectomy/methods

KW - Survival Rate

KW - Survival Analysis

KW - Adult

U2 - 10.1093/bjs/znae087

DO - 10.1093/bjs/znae087

M3 - Article

SN - 0007-1323

VL - 111

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 4

M1 - znae087

ER -

Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort

Abstract

Keywords

Access to Document

Fingerprint

Cite this