Abstract
Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.
Original language | English |
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Pages (from-to) | 2824-2839 |
Number of pages | 16 |
Journal | Human Reproduction |
Volume | 36 |
Issue number | 11 |
DOIs | |
Publication status | Published - 18 Oct 2021 |
Keywords
- Artificial Intelligence
- Biomarkers, Tumor
- Biopsy
- Cell-Free Nucleic Acids
- Humans
- Liquid Biopsy
- Neoplasms
- Reproductive Medicine
- preimplantation genetic testing
- ART
- EMBRYO CULTURE-MEDIUM
- artificial intelligence
- INCIDENTAL DETECTION
- NONINVASIVE PRENATAL-DIAGNOSIS
- MATERNAL PLASMA
- GENE-EXPRESSION
- liquid biopsy
- GENOMIC DNA
- CELL-FREE DNA
- non-invasive prenatal testing
- circulating cells
- next generation sequencing
- MITOCHONDRIAL-DNA
- FREE FETAL DNA
- CIRCULATING TUMOR-CELLS
- spent embryo culture medium
- cell-free DNA
- IVF