Liquid biopsy: state of reproductive medicine and beyond

Gaby Schobers; Rebekka Koeck; Dominique Pellaers; Servi J C Stevens; Merryn V E Macville; Aimée D C Paulussen; Edith Coonen; Arthur van den Wijngaard; Christine de Die-Smulders; Guido de Wert; Han G Brunner; Masoud Zamani Esteki

doi:10.1093/humrep/deab206

Liquid biopsy: state of reproductive medicine and beyond

Gaby Schobers, Rebekka Koeck, Dominique Pellaers, Servi J C Stevens, Merryn V E Macville, Aimée D C Paulussen, Edith Coonen, Arthur van den Wijngaard, Christine de Die-Smulders, Guido de Wert, Han G Brunner, Masoud Zamani Esteki^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

4 Citations (Web of Science)

Abstract

Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.

Original language	English
Pages (from-to)	2824-2839
Number of pages	16
Journal	Human Reproduction
Volume	36
Issue number	11
DOIs	https://doi.org/10.1093/humrep/deab206
Publication status	Published - 18 Oct 2021

Keywords

Artificial Intelligence
Biomarkers, Tumor
Biopsy
Cell-Free Nucleic Acids
Humans
Liquid Biopsy
Neoplasms
Reproductive Medicine
preimplantation genetic testing
ART
EMBRYO CULTURE-MEDIUM
artificial intelligence
INCIDENTAL DETECTION
NONINVASIVE PRENATAL-DIAGNOSIS
MATERNAL PLASMA
GENE-EXPRESSION
liquid biopsy
GENOMIC DNA
CELL-FREE DNA
non-invasive prenatal testing
circulating cells
next generation sequencing
MITOCHONDRIAL-DNA
FREE FETAL DNA
CIRCULATING TUMOR-CELLS
spent embryo culture medium
cell-free DNA
IVF

Access to Document

10.1093/humrep/deab206

Cite this

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title = "Liquid biopsy: state of reproductive medicine and beyond",

abstract = "Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.",

keywords = "Artificial Intelligence, Biomarkers, Tumor, Biopsy, Cell-Free Nucleic Acids, Humans, Liquid Biopsy, Neoplasms, Reproductive Medicine, preimplantation genetic testing, ART, EMBRYO CULTURE-MEDIUM, artificial intelligence, INCIDENTAL DETECTION, NONINVASIVE PRENATAL-DIAGNOSIS, MATERNAL PLASMA, GENE-EXPRESSION, liquid biopsy, GENOMIC DNA, CELL-FREE DNA, non-invasive prenatal testing, circulating cells, next generation sequencing, MITOCHONDRIAL-DNA, FREE FETAL DNA, CIRCULATING TUMOR-CELLS, spent embryo culture medium, cell-free DNA, IVF",

author = "Gaby Schobers and Rebekka Koeck and Dominique Pellaers and Stevens, {Servi J C} and Macville, {Merryn V E} and Paulussen, {Aim{\'e}e D C} and Edith Coonen and {van den Wijngaard}, Arthur and {de Die-Smulders}, Christine and {de Wert}, Guido and Brunner, {Han G} and {Zamani Esteki}, Masoud",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.",

year = "2021",

month = oct,

day = "18",

doi = "10.1093/humrep/deab206",

language = "English",

volume = "36",

pages = "2824--2839",

journal = "Human Reproduction",

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TY - JOUR

T1 - Liquid biopsy

T2 - state of reproductive medicine and beyond

AU - Schobers, Gaby

AU - Koeck, Rebekka

AU - Pellaers, Dominique

AU - Stevens, Servi J C

AU - Macville, Merryn V E

AU - Paulussen, Aimée D C

AU - Coonen, Edith

AU - van den Wijngaard, Arthur

AU - de Die-Smulders, Christine

AU - de Wert, Guido

AU - Brunner, Han G

AU - Zamani Esteki, Masoud

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

PY - 2021/10/18

Y1 - 2021/10/18

N2 - Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.

AB - Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.

KW - Artificial Intelligence

KW - Biomarkers, Tumor

KW - Biopsy

KW - Cell-Free Nucleic Acids

KW - Humans

KW - Liquid Biopsy

KW - Neoplasms

KW - Reproductive Medicine

KW - preimplantation genetic testing

KW - ART

KW - EMBRYO CULTURE-MEDIUM

KW - artificial intelligence

KW - INCIDENTAL DETECTION

KW - NONINVASIVE PRENATAL-DIAGNOSIS

KW - MATERNAL PLASMA

KW - GENE-EXPRESSION

KW - liquid biopsy

KW - GENOMIC DNA

KW - CELL-FREE DNA

KW - non-invasive prenatal testing

KW - circulating cells

KW - next generation sequencing

KW - MITOCHONDRIAL-DNA

KW - FREE FETAL DNA

KW - CIRCULATING TUMOR-CELLS

KW - spent embryo culture medium

KW - cell-free DNA

KW - IVF

U2 - 10.1093/humrep/deab206

DO - 10.1093/humrep/deab206

M3 - (Systematic) Review article

C2 - 34562078

SN - 0268-1161

VL - 36

SP - 2824

EP - 2839

JO - Human Reproduction

JF - Human Reproduction

IS - 11

ER -