Lipids and lipoproteins in cardiovascular diseases: a classification

Shruti Bhargava; Sofia de la Puente-Secades; Leon Schurgers; Joachim Jankowski

doi:10.1016/j.tem.2022.02.001

Lipids and lipoproteins in cardiovascular diseases: a classification

Shruti Bhargava, Sofia de la Puente-Secades, Leon Schurgers, Joachim Jankowski^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.

Original language	English
Pages (from-to)	409-423
Number of pages	15
Journal	Trends in Endocrinology and Metabolism
Volume	33
Issue number	6
Early online date	31 Mar 2022
DOIs	https://doi.org/10.1016/j.tem.2022.02.001
Publication status	Published - Jun 2022

Keywords

APOA-I
APOLIPOPROTEIN C-III
ATHEROSCLEROTIC LESIONS
CHOLESTEROL
CORONARY-HEART-DISEASE
HDL
HIGH-DENSITY-LIPOPROTEIN
PARTICLE NUMBER
POLYUNSATURATED FATTY-ACIDS
RISK

Access to Document

10.1016/j.tem.2022.02.001Licence: CC BY

Cite this

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title = "Lipids and lipoproteins in cardiovascular diseases: a classification",

abstract = "Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.",

keywords = "APOA-I, APOLIPOPROTEIN C-III, ATHEROSCLEROTIC LESIONS, CHOLESTEROL, CORONARY-HEART-DISEASE, HDL, HIGH-DENSITY-LIPOPROTEIN, PARTICLE NUMBER, POLYUNSATURATED FATTY-ACIDS, RISK",

author = "Shruti Bhargava and {de la Puente-Secades}, Sofia and Leon Schurgers and Joachim Jankowski",

year = "2022",

month = jun,

doi = "10.1016/j.tem.2022.02.001",

language = "English",

volume = "33",

pages = "409--423",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Science",

number = "6",

}

TY - JOUR

T1 - Lipids and lipoproteins in cardiovascular diseases

T2 - a classification

AU - Bhargava, Shruti

AU - de la Puente-Secades, Sofia

AU - Schurgers, Leon

AU - Jankowski, Joachim

PY - 2022/6

Y1 - 2022/6

N2 - Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.

AB - Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.

KW - APOA-I

KW - APOLIPOPROTEIN C-III

KW - ATHEROSCLEROTIC LESIONS

KW - CHOLESTEROL

KW - CORONARY-HEART-DISEASE

KW - HDL

KW - HIGH-DENSITY-LIPOPROTEIN

KW - PARTICLE NUMBER

KW - POLYUNSATURATED FATTY-ACIDS

KW - RISK

U2 - 10.1016/j.tem.2022.02.001

DO - 10.1016/j.tem.2022.02.001

M3 - (Systematic) Review article

C2 - 35370062

SN - 1043-2760

VL - 33

SP - 409

EP - 423

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 6

ER -