Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes

Namam Ali; Anna W. M. Janssen; Martin Jaeger; Lisa Van de Wijer; Wouter van Der Heijden; Rob ter Horst; Priya Vart; Alain van Gool; Leo A. B. Joosten; Mihai G. Netea; Rinke Stienstra; Bastiaan E. De Galan; Cees J. Tack

doi:10.1111/dom.14172

Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes

Namam Ali^*
, Anna W. M. Janssen
, Martin Jaeger
, Lisa Van de Wijer
, Wouter van Der Heijden
, Rob ter Horst
, Priya Vart
, Alain van Gool
, Leo A. B. Joosten
, Mihai G. Netea
, Rinke Stienstra
, Bastiaan E. De Galan
, Cees J. Tack

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim To investigate whether a history of severe hypoglycaemia (SH) or the associated presence of impaired awareness of hypoglycaemia (IAH) is characterized by a pro-inflammatory profile in people with type 1 diabetes. Research design and methods We measured circulating inflammatory markers and pro- and anti-inflammatory cytokine production afterex vivostimulation of peripheral blood mononuclear cells (PBMCs) in a well-characterized cohort of individuals with type 1 diabetes (n = 239) and in people without diabetes (n = 56). Data were corrected for confounders by using multivariate linear regression models. Results People with type 1 diabetes had higher circulating concentrations of high-sensitivity C-reactive protein (hs-CRP; 0.91 [0.36-2.25] vs. 0.52 [0.20-0.98] pg/mL,P

Original language	English
Pages (from-to)	2427-2436
Number of pages	10
Journal	Diabetes Obesity & Metabolism
Volume	22
Issue number	12
Early online date	22 Sept 2020
DOIs	https://doi.org/10.1111/dom.14172
Publication status	Published - Dec 2020

Keywords

cardiovascular disease
cohort study
diabetes complications
hypoglycaemia
type 1 diabetes
CARDIOVASCULAR-DISEASE
INTERLEUKIN-18
ATHEROSCLEROSIS
MORTALITY
EVENTS
IMMUNE
SERUM
RISK
ASSOCIATION
MECHANISMS

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Ali, N., Janssen, A. W. M., Jaeger, M., Van de Wijer, L., van Der Heijden, W., ter Horst, R., Vart, P., van Gool, A., Joosten, L. A. B., Netea, M. G., Stienstra, R., De Galan, B. E., & Tack, C. J. (2020). Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes. Diabetes Obesity & Metabolism, 22(12), 2427-2436. https://doi.org/10.1111/dom.14172

@article{122911db6df34742b7d93071b85f1ab3,

title = "Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes",

abstract = "Aim To investigate whether a history of severe hypoglycaemia (SH) or the associated presence of impaired awareness of hypoglycaemia (IAH) is characterized by a pro-inflammatory profile in people with type 1 diabetes. Research design and methods We measured circulating inflammatory markers and pro- and anti-inflammatory cytokine production afterex vivostimulation of peripheral blood mononuclear cells (PBMCs) in a well-characterized cohort of individuals with type 1 diabetes (n = 239) and in people without diabetes (n = 56). Data were corrected for confounders by using multivariate linear regression models. Results People with type 1 diabetes had higher circulating concentrations of high-sensitivity C-reactive protein (hs-CRP; 0.91 [0.36-2.25] vs. 0.52 [0.20-0.98] pg/mL,P",

keywords = "cardiovascular disease, cohort study, diabetes complications, hypoglycaemia, type 1 diabetes, CARDIOVASCULAR-DISEASE, INTERLEUKIN-18, ATHEROSCLEROSIS, MORTALITY, EVENTS, IMMUNE, SERUM, RISK, ASSOCIATION, MECHANISMS",

author = "Namam Ali and Janssen, \{Anna W. M.\} and Martin Jaeger and \{Van de Wijer\}, Lisa and \{van Der Heijden\}, Wouter and \{ter Horst\}, Rob and Priya Vart and \{van Gool\}, Alain and Joosten, \{Leo A. B.\} and Netea, \{Mihai G.\} and Rinke Stienstra and \{De Galan\}, \{Bastiaan E.\} and Tack, \{Cees J.\}",

note = "Funding Information: The authors thank all the volunteers for their participation. The authors also thank Sanne Smeekens and Marije Doppenberg-Oosting for assistance during the setup of this study, Clementine Verhulst for recruiting study participants, Sanne Smeekens and Lian van Meijel for assisting during the clinical visits, and Sanne Smeekens, Heidi Lemmers and Helga Dijkstra for assistance during experimental bench work. Publisher Copyright: {\textcopyright} 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley \& Sons Ltd.",

year = "2020",

month = dec,

doi = "10.1111/dom.14172",

language = "English",

volume = "22",

pages = "2427--2436",

journal = "Diabetes Obesity \& Metabolism",

issn = "1462-8902",

publisher = "John Wiley \& Sons Inc.",

number = "12",

}

Ali, N, Janssen, AWM, Jaeger, M, Van de Wijer, L, van Der Heijden, W, ter Horst, R, Vart, P, van Gool, A, Joosten, LAB, Netea, MG, Stienstra, R, De Galan, BE & Tack, CJ 2020, 'Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes', Diabetes Obesity & Metabolism, vol. 22, no. 12, pp. 2427-2436. https://doi.org/10.1111/dom.14172

TY - JOUR

T1 - Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes

AU - Ali, Namam

AU - Janssen, Anna W. M.

AU - Jaeger, Martin

AU - Van de Wijer, Lisa

AU - van Der Heijden, Wouter

AU - ter Horst, Rob

AU - Vart, Priya

AU - van Gool, Alain

AU - Joosten, Leo A. B.

AU - Netea, Mihai G.

AU - Stienstra, Rinke

AU - De Galan, Bastiaan E.

AU - Tack, Cees J.

N1 - Funding Information: The authors thank all the volunteers for their participation. The authors also thank Sanne Smeekens and Marije Doppenberg-Oosting for assistance during the setup of this study, Clementine Verhulst for recruiting study participants, Sanne Smeekens and Lian van Meijel for assisting during the clinical visits, and Sanne Smeekens, Heidi Lemmers and Helga Dijkstra for assistance during experimental bench work. Publisher Copyright: © 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

PY - 2020/12

Y1 - 2020/12

N2 - Aim To investigate whether a history of severe hypoglycaemia (SH) or the associated presence of impaired awareness of hypoglycaemia (IAH) is characterized by a pro-inflammatory profile in people with type 1 diabetes. Research design and methods We measured circulating inflammatory markers and pro- and anti-inflammatory cytokine production afterex vivostimulation of peripheral blood mononuclear cells (PBMCs) in a well-characterized cohort of individuals with type 1 diabetes (n = 239) and in people without diabetes (n = 56). Data were corrected for confounders by using multivariate linear regression models. Results People with type 1 diabetes had higher circulating concentrations of high-sensitivity C-reactive protein (hs-CRP; 0.91 [0.36-2.25] vs. 0.52 [0.20-0.98] pg/mL,P

AB - Aim To investigate whether a history of severe hypoglycaemia (SH) or the associated presence of impaired awareness of hypoglycaemia (IAH) is characterized by a pro-inflammatory profile in people with type 1 diabetes. Research design and methods We measured circulating inflammatory markers and pro- and anti-inflammatory cytokine production afterex vivostimulation of peripheral blood mononuclear cells (PBMCs) in a well-characterized cohort of individuals with type 1 diabetes (n = 239) and in people without diabetes (n = 56). Data were corrected for confounders by using multivariate linear regression models. Results People with type 1 diabetes had higher circulating concentrations of high-sensitivity C-reactive protein (hs-CRP; 0.91 [0.36-2.25] vs. 0.52 [0.20-0.98] pg/mL,P

KW - cardiovascular disease

KW - cohort study

KW - diabetes complications

KW - hypoglycaemia

KW - type 1 diabetes

KW - CARDIOVASCULAR-DISEASE

KW - INTERLEUKIN-18

KW - ATHEROSCLEROSIS

KW - MORTALITY

KW - EVENTS

KW - IMMUNE

KW - SERUM

KW - RISK

KW - ASSOCIATION

KW - MECHANISMS

U2 - 10.1111/dom.14172

DO - 10.1111/dom.14172

M3 - Article

C2 - 33462962

SN - 1462-8902

VL - 22

SP - 2427

EP - 2436

JO - Diabetes Obesity & Metabolism

JF - Diabetes Obesity & Metabolism

IS - 12

ER -

Limited impact of impaired awareness of hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1 diabetes

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Keywords

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