LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

Chantal Kroone; Mariska Vos; Timo Rademakers; Marijke Kuijpers; Mark Hoogenboezem; Jaap van Buul; Johan W M Heemskerk; Wolfram Ruf; Astrid van Hylckama Vlieg; Henri H Versteeg; Marie-José Goumans; Carlie J M de Vries; Kondababu Kurakula; INVENT Consortium

doi:10.3324/haematol.2018.203026

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

Chantal Kroone, Mariska Vos, Timo Rademakers, Marijke Kuijpers, Mark Hoogenboezem, Jaap van Buul, Johan W M Heemskerk, Wolfram Ruf, Astrid van Hylckama Vlieg, Henri H Versteeg, Marie-José Goumans, Carlie J M de Vries, Kondababu Kurakula^*, INVENT Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Web of Science)

Original language	English
Pages (from-to)	1677-1685
Number of pages	9
Journal	Haematologica-the Hematology Journal
Volume	105
Issue number	6
Early online date	29 Aug 2019
DOIs	https://doi.org/10.3324/haematol.2018.203026
Publication status	Published - Jun 2020

Keywords

SMOOTH-MUSCLE-CELLS
FACTOR EXPRESSION
PROCOAGULANT ACTIVITY
ENDOTHELIAL-CELLS
COAGULATION
ACTIVATION
THROMBOMODULIN
RECEPTORS
INDUCTION
MONOCYTES

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Kroone, C., Vos, M., Rademakers, T., Kuijpers, M., Hoogenboezem, M., van Buul, J., Heemskerk, J. W. M., Ruf, W., van Hylckama Vlieg, A., Versteeg, H. H., Goumans, M-J., de Vries, C. J. M., Kurakula, K., & INVENT Consortium (2020). LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis. Haematologica-the Hematology Journal, 105(6), 1677-1685. https://doi.org/10.3324/haematol.2018.203026

Kroone, Chantal ; Vos, Mariska ; Rademakers, Timo ; Kuijpers, Marijke ; Hoogenboezem, Mark ; van Buul, Jaap ; Heemskerk, Johan W M ; Ruf, Wolfram ; van Hylckama Vlieg, Astrid ; Versteeg, Henri H ; Goumans, Marie-José ; de Vries, Carlie J M ; Kurakula, Kondababu ; INVENT Consortium. / LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis. In: Haematologica-the Hematology Journal. 2020 ; Vol. 105, No. 6. pp. 1677-1685.

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title = "LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis",

keywords = "SMOOTH-MUSCLE-CELLS, FACTOR EXPRESSION, PROCOAGULANT ACTIVITY, ENDOTHELIAL-CELLS, COAGULATION, ACTIVATION, THROMBOMODULIN, RECEPTORS, INDUCTION, MONOCYTES",

author = "Chantal Kroone and Mariska Vos and Timo Rademakers and Marijke Kuijpers and Mark Hoogenboezem and {van Buul}, Jaap and Heemskerk, {Johan W M} and Wolfram Ruf and {van Hylckama Vlieg}, Astrid and Versteeg, {Henri H} and Marie-Jos{\'e} Goumans and {de Vries}, {Carlie J M} and Kondababu Kurakula and {INVENT Consortium}",

note = "Copyright {\textcopyright} 2019, Ferrata Storti Foundation.",

year = "2020",

month = jun,

doi = "10.3324/haematol.2018.203026",

language = "English",

volume = "105",

pages = "1677--1685",

journal = "Haematologica-the Hematology Journal",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "6",

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Kroone, C, Vos, M, Rademakers, T , Kuijpers, M, Hoogenboezem, M, van Buul, J, Heemskerk, JWM, Ruf, W, van Hylckama Vlieg, A, Versteeg, HH, Goumans, M-J, de Vries, CJM, Kurakula, K & INVENT Consortium 2020, 'LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis', Haematologica-the Hematology Journal, vol. 105, no. 6, pp. 1677-1685. https://doi.org/10.3324/haematol.2018.203026

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis. / Kroone, Chantal; Vos, Mariska; Rademakers, Timo ; Kuijpers, Marijke; Hoogenboezem, Mark; van Buul, Jaap; Heemskerk, Johan W M; Ruf, Wolfram; van Hylckama Vlieg, Astrid; Versteeg, Henri H; Goumans, Marie-José; de Vries, Carlie J M; Kurakula, Kondababu; INVENT Consortium.

In: Haematologica-the Hematology Journal, Vol. 105, No. 6, 06.2020, p. 1677-1685.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

AU - Kroone, Chantal

AU - Vos, Mariska

AU - Rademakers, Timo

AU - Kuijpers, Marijke

AU - Hoogenboezem, Mark

AU - van Buul, Jaap

AU - Heemskerk, Johan W M

AU - Ruf, Wolfram

AU - van Hylckama Vlieg, Astrid

AU - Versteeg, Henri H

AU - Goumans, Marie-José

AU - de Vries, Carlie J M

AU - Kurakula, Kondababu

AU - INVENT Consortium

PY - 2020/6

Y1 - 2020/6

KW - SMOOTH-MUSCLE-CELLS

KW - FACTOR EXPRESSION

KW - PROCOAGULANT ACTIVITY

KW - ENDOTHELIAL-CELLS

KW - COAGULATION

KW - ACTIVATION

KW - THROMBOMODULIN

KW - RECEPTORS

KW - INDUCTION

KW - MONOCYTES

U2 - 10.3324/haematol.2018.203026

DO - 10.3324/haematol.2018.203026

M3 - Article

C2 - 31467128

VL - 105

SP - 1677

EP - 1685

JO - Haematologica-the Hematology Journal

JF - Haematologica-the Hematology Journal

SN - 0390-6078

IS - 6

ER -