Lifetime costs and effectiveness of ReSTOR compared with a monofocal IOL and Array-SA40 in the Netherlands

N. E. De Vries, C. Laurendeau, A. Lafuma, G. Berdeaux*, R. M. M. A. Nuijts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose To estimate the lifetime cost consequences for society and the National Health Service (NHS) of bilateral monofocal (SI40NB) or multifocal (ReSTOR or Array-SA40) intraocular lense (IOL) implantation after cataract surgery. Setting Public hospital in the Netherlands. Methods A Markov model simulated three cohorts of patients followed 69 until 100 years of age, or death. Spectacle independence rates for each IOL were adjusted to the results of a randomized clinical trial that compared monofocal and multifocal Array-SA40 IOL implants, together with a prospective cohort of patients implanted with ReSTOR. Adjustment was performed using the propensity score method in a multivariate analysis. Resource consumption was estimated from a dedicated Dutch survey. Dutch unit costs were applied to spectacles, cataract surgery, IOLs, visits to ophthalmologists, optometrists, transport, and spectacle cleaning materials. Cost discounted at 4% and undiscounted economic results were calculated. Results Spectacle independence rates were 86.0% for ReSTOR, 8.7% for monofocal IOLs, and 8.5% for Array-SA40. Patients lived without needing spectacles for 12.9 years after ReSTOR, for 1.4 years after monofocal IOLs, and 1.3 years after Array-SA40. ReSTOR patients bought 6.4 fewer pairs of spectacles than monofocal patients. Lifetime discounted cost consequences for the society were ReSTOR (sic)3969, monofocal IOLs (sic)4123, and Array-SA40 (sic)5326. Corresponding costs for the NHS were (sic)2415, (sic)2555, and (sic)2556, respectively. Conclusions ReSTOR IOLs provided higher levels of spectacle independence than monofocal SI40NB or multifocal Array-SA40 IOLs resulting in savings, compared to a monofocal, over the period modelled of (sic)315 for society and (sic)140 for the NHS. Eye (2010) 24, 663-672; doi:10.1038/eye.2009.151; published online 3 July 2009
Original languageEnglish
Pages (from-to)663-672
Issue number4
Publication statusPublished - Apr 2010


  • cataract surgery
  • spectacle freedom
  • cost minimization
  • multifocal intraocular lens

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