Lifestyle for Brain Health (LIBRA): a new model for dementia prevention

Olga J. G. Schiepers; Sebastian Kohler; Kay Deckers; Kate Irving; Catherine A. O'Donnell; Marjan van den Akker; Frans R. J. Verhey; Stephanie J. B. Vos; Marjolein E. de Vugt; Martin P. J. van Boxtel

doi:10.1002/gps.4700

Lifestyle for Brain Health (LIBRA): a new model for dementia prevention

Olga J. G. Schiepers, Sebastian Kohler, Kay Deckers, Kate Irving, Catherine A. O'Donnell, Marjan van den Akker, Frans R. J. Verhey, Stephanie J. B. Vos, Marjolein E. de Vugt, Martin P. J. van Boxtel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Web of Science)

162 Downloads (Pure)

Abstract

ObjectiveModifiable risk factors for dementia were recently identified and compiled in a systematic review. The Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16years. MethodsLifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline. ResultsLifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning. ConclusionsLifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors.

Original language	English
Pages (from-to)	167-175
Number of pages	9
Journal	International Journal of Geriatric Psychiatry
Volume	33
Issue number	1
DOIs	https://doi.org/10.1002/gps.4700
Publication status	Published - Jan 2018

Keywords

dementia
prevention
lifestyle
ageing
cognitive function

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10.1002/gps.4700

Full textFinal published version, 232 KBLicence: Taverne

45 Citations
1 Erratum / corrigendum / retractions

Corrigendum: Lifestyle for Brain Health (LIBRA): a new model for dementia prevention (vol 33, pg 167, 2018)
Schiepers, O. J. G., Kohler, S., Deckers, K., Irving, K., O'Donnell, C. A., van den Akker, M., Verhey, F. R. J., Vos, S. J. B., de Vugt, M. E. & van Boxtel, M. P. J., Sep 2018, In: International Journal of Geriatric Psychiatry. 33, 9, p. 1290
Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

Cite this

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title = "Lifestyle for Brain Health (LIBRA): a new model for dementia prevention",

abstract = "ObjectiveModifiable risk factors for dementia were recently identified and compiled in a systematic review. The Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16years. MethodsLifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline. ResultsLifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning. ConclusionsLifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. ",

keywords = "dementia, prevention, lifestyle, ageing, cognitive function",

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year = "2018",

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AU - O'Donnell, Catherine A.

AU - van den Akker, Marjan

AU - Verhey, Frans R. J.

AU - Vos, Stephanie J. B.

AU - de Vugt, Marjolein E.

AU - van Boxtel, Martin P. J.

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N2 - ObjectiveModifiable risk factors for dementia were recently identified and compiled in a systematic review. The Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16years. MethodsLifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline. ResultsLifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning. ConclusionsLifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors.

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Lifestyle for Brain Health (LIBRA): a new model for dementia prevention

Abstract

Keywords

Access to Document

Research output

Corrigendum: Lifestyle for Brain Health (LIBRA): a new model for dementia prevention (vol 33, pg 167, 2018)

Cite this