Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis

Stephanie Van Asbroeck; Sebastian Köhler; Martin P J van Boxtel; Darren M Lipnicki; John D Crawford; Erico Castro-Costa; Maria Fernanda Lima-Costa; Sergio Luis Blay; Xiao Shifu; Tao Wang; Ling Yue; Richard B Lipton; Mindy J Katz; Carol A Derby; Maëlenn Guerchet; Pierre-Marie Preux; Pascal Mbelesso; Joanna Norton; Karen Ritchie; Ingmar Skoog; Jenna Najar; Therese Rydberg Sterner; Nikolaos Scarmeas; Mary Yannakoulia; Themis Dardiotis; Elena Rolandi; Annalisa Davin; Michele Rossi; Oye Gureje; Akin Ojagbemi; Toyin Bello; Ki Woong Kim; Ji Won Han; Dae Jong Oh; Stella Trompet; Jacobijn Gussekloo; Steffi G Riedel-Heller; Susanne Röhr; Alexander Pabst; Suzana Shahar; Nurul Fatin Malek Rivan; Devinder Kaur Ajit Singh; Erin Jacobsen; Mary Ganguli; Tiffany Hughes; Mary Haan; Allison E Aiello; Ding Ding; Qianhua Zhao; Zhenxu Xiao; for Cohort Studies of Memory in an International Consortium (COSMIC); Kay Deckers

doi:10.1002/alz.13846

Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis

Stephanie Van Asbroeck, Sebastian Köhler, Martin P J van Boxtel, Darren M Lipnicki, John D Crawford, Erico Castro-Costa, Maria Fernanda Lima-Costa, Sergio Luis Blay, Xiao Shifu, Tao Wang, Ling Yue, Richard B Lipton, Mindy J Katz, Carol A Derby, Maëlenn Guerchet, Pierre-Marie Preux, Pascal Mbelesso, Joanna Norton, Karen Ritchie, Ingmar SkoogJenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Elena Rolandi, Annalisa Davin, Michele Rossi, Oye Gureje, Akin Ojagbemi, Toyin Bello, Ki Woong Kim, Ji Won Han, Dae Jong Oh, Stella Trompet, Jacobijn Gussekloo, Steffi G Riedel-Heller, Susanne Röhr, Alexander Pabst, Suzana Shahar, Nurul Fatin Malek Rivan, Devinder Kaur Ajit Singh, Erin Jacobsen, Mary Ganguli, Tiffany Hughes, Mary Haan, Allison E Aiello, Ding Ding, Qianhua Zhao, Zhenxu Xiao, for Cohort Studies of Memory in an International Consortium (COSMIC), Kay Deckers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged =75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.

Original language	English
Pages (from-to)	3972-3986
Number of pages	15
Journal	Alzheimer's & Dementia
Volume	20
Issue number	6
Early online date	2024
DOIs	https://doi.org/10.1002/alz.13846
Publication status	Published - Jun 2024

Keywords

age
dementia
dementia risk reduction
education
effect modification
ethnicity
individual participant data meta-analysis
interaction
lifestyle
primary prevention
region
risk factor
risk personalization
sex
socioeconomic

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Van Asbroeck, S., Köhler, S., van Boxtel, M. P. J., Lipnicki, D. M., Crawford, J. D., Castro-Costa, E., Lima-Costa, M. F., Blay, S. L., Shifu, X., Wang, T., Yue, L., Lipton, R. B., Katz, M. J., Derby, C. A., Guerchet, M., Preux, P.-M., Mbelesso, P., Norton, J., Ritchie, K., ... Deckers, K. (2024). Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis. Alzheimer's & Dementia, 20(6), 3972-3986. https://doi.org/10.1002/alz.13846

@article{24611cc512da47e0949590cd5e373ad7,

title = "Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis",

abstract = "INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21\% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged =75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.",

keywords = "age, dementia, dementia risk reduction, education, effect modification, ethnicity, individual participant data meta-analysis, interaction, lifestyle, primary prevention, region, risk factor, risk personalization, sex, socioeconomic",

author = "\{Van Asbroeck\}, Stephanie and Sebastian K{\"o}hler and \{van Boxtel\}, \{Martin P J\} and Lipnicki, \{Darren M\} and Crawford, \{John D\} and Erico Castro-Costa and Lima-Costa, \{Maria Fernanda\} and Blay, \{Sergio Luis\} and Xiao Shifu and Tao Wang and Ling Yue and Lipton, \{Richard B\} and Katz, \{Mindy J\} and Derby, \{Carol A\} and Ma{\"e}lenn Guerchet and Pierre-Marie Preux and Pascal Mbelesso and Joanna Norton and Karen Ritchie and Ingmar Skoog and Jenna Najar and Sterner, \{Therese Rydberg\} and Nikolaos Scarmeas and Mary Yannakoulia and Themis Dardiotis and Elena Rolandi and Annalisa Davin and Michele Rossi and Oye Gureje and Akin Ojagbemi and Toyin Bello and Kim, \{Ki Woong\} and Han, \{Ji Won\} and Oh, \{Dae Jong\} and Stella Trompet and Jacobijn Gussekloo and Riedel-Heller, \{Steffi G\} and Susanne R{\"o}hr and Alexander Pabst and Suzana Shahar and Rivan, \{Nurul Fatin Malek\} and Singh, \{Devinder Kaur Ajit\} and Erin Jacobsen and Mary Ganguli and Tiffany Hughes and Mary Haan and Aiello, \{Allison E\} and Ding Ding and Qianhua Zhao and Zhenxu Xiao and \{for Cohort Studies of Memory in an International Consortium (COSMIC)\} and Kay Deckers",

year = "2024",

month = jun,

doi = "10.1002/alz.13846",

language = "English",

volume = "20",

pages = "3972--3986",

journal = "Alzheimer's \& Dementia",

issn = "1552-5260",

publisher = "John Wiley \& Sons Inc.",

number = "6",

}

Van Asbroeck, S, Köhler, S , van Boxtel, MPJ, Lipnicki, DM, Crawford, JD, Castro-Costa, E, Lima-Costa, MF, Blay, SL, Shifu, X, Wang, T, Yue, L, Lipton, RB, Katz, MJ, Derby, CA, Guerchet, M, Preux, P-M, Mbelesso, P, Norton, J, Ritchie, K, Skoog, I, Najar, J, Sterner, TR, Scarmeas, N, Yannakoulia, M, Dardiotis, T, Rolandi, E, Davin, A, Rossi, M, Gureje, O, Ojagbemi, A, Bello, T, Kim, KW, Han, JW, Oh, DJ, Trompet, S, Gussekloo, J, Riedel-Heller, SG, Röhr, S, Pabst, A, Shahar, S, Rivan, NFM, Singh, DKA, Jacobsen, E, Ganguli, M, Hughes, T, Haan, M, Aiello, AE, Ding, D, Zhao, Q, Xiao, Z, for Cohort Studies of Memory in an International Consortium (COSMIC) & Deckers, K 2024, 'Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis', Alzheimer's & Dementia, vol. 20, no. 6, pp. 3972-3986. https://doi.org/10.1002/alz.13846

TY - JOUR

T1 - Lifestyle and incident dementia

T2 - A COSMIC individual participant data meta-analysis

AU - Van Asbroeck, Stephanie

AU - Köhler, Sebastian

AU - van Boxtel, Martin P J

AU - Lipnicki, Darren M

AU - Crawford, John D

AU - Castro-Costa, Erico

AU - Lima-Costa, Maria Fernanda

AU - Blay, Sergio Luis

AU - Shifu, Xiao

AU - Wang, Tao

AU - Yue, Ling

AU - Lipton, Richard B

AU - Katz, Mindy J

AU - Derby, Carol A

AU - Guerchet, Maëlenn

AU - Preux, Pierre-Marie

AU - Mbelesso, Pascal

AU - Norton, Joanna

AU - Ritchie, Karen

AU - Skoog, Ingmar

AU - Najar, Jenna

AU - Sterner, Therese Rydberg

AU - Scarmeas, Nikolaos

AU - Yannakoulia, Mary

AU - Dardiotis, Themis

AU - Rolandi, Elena

AU - Davin, Annalisa

AU - Rossi, Michele

AU - Gureje, Oye

AU - Ojagbemi, Akin

AU - Bello, Toyin

AU - Kim, Ki Woong

AU - Han, Ji Won

AU - Oh, Dae Jong

AU - Trompet, Stella

AU - Gussekloo, Jacobijn

AU - Riedel-Heller, Steffi G

AU - Röhr, Susanne

AU - Pabst, Alexander

AU - Shahar, Suzana

AU - Rivan, Nurul Fatin Malek

AU - Singh, Devinder Kaur Ajit

AU - Jacobsen, Erin

AU - Ganguli, Mary

AU - Hughes, Tiffany

AU - Haan, Mary

AU - Aiello, Allison E

AU - Ding, Ding

AU - Zhao, Qianhua

AU - Xiao, Zhenxu

AU - for Cohort Studies of Memory in an International Consortium (COSMIC)

AU - Deckers, Kay

PY - 2024/6

Y1 - 2024/6

N2 - INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged =75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.

AB - INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged =75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.

KW - age

KW - dementia

KW - dementia risk reduction

KW - education

KW - effect modification

KW - ethnicity

KW - individual participant data meta-analysis

KW - interaction

KW - lifestyle

KW - primary prevention

KW - region

KW - risk factor

KW - risk personalization

KW - sex

KW - socioeconomic

U2 - 10.1002/alz.13846

DO - 10.1002/alz.13846

M3 - Article

SN - 1552-5260

VL - 20

SP - 3972

EP - 3986

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 6

ER -

Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis

Abstract

Keywords

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