Life and death at the mucosal luminal interface: A new perspective on human intestinal ischemia/reperfusion

J. Grootjans

Research output: ThesisDoctoral ThesisInternal

Abstract

Shortage of oxygen (ischemia) of the intestine is a potentially life threatening disorder. To gain more insight in the underlying causes our research group developed unique human intestinal ischemia/reperfusion (IR) models. Reperfusion is recovery of the blood supply to tissues that were earlier (partly) devoid of blood. Grootjans discovered that the small intestine disposes of ingenious mechanisms to limit damage to the intestinal wall after short periods of IR. He also discovered that longer ischemia with reperfusion involves damage to the congenital defence of the intestine, which contributes to the development of complications of intestinal ischemia. Future studies now focus on the development of treatments that can reduce death by intestinal ischemia in the future.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Buurman, Willem, Supervisor
  • Dejong, Kees, Supervisor
Award date2 Nov 2012
Place of PublicationMaastricht
Publisher
Publication statusPublished - 1 Jan 2012

Keywords

  • intestinal ischemia
  • causes
  • small intestine

Cite this