Shortage of oxygen (ischemia) of the intestine is a potentially life threatening disorder. To gain more insight in the underlying causes our research group developed unique human intestinal ischemia/reperfusion (IR) models. Reperfusion is recovery of the blood supply to tissues that were earlier (partly) devoid of blood. Grootjans discovered that the small intestine disposes of ingenious mechanisms to limit damage to the intestinal wall after short periods of IR. He also discovered that longer ischemia with reperfusion involves damage to the congenital defence of the intestine, which contributes to the development of complications of intestinal ischemia. Future studies now focus on the development of treatments that can reduce death by intestinal ischemia in the future.
|Qualification||Doctor of Philosophy|
|Award date||2 Nov 2012|
|Place of Publication||Maastricht|
|Publication status||Published - 1 Jan 2012|
- intestinal ischemia
- small intestine