@article{782587ff7b6e4c26bb5968cc6a8a4fec,
title = "Leveling Up Hydrogels: Hybrid Systems in Tissue Engineering",
abstract = "Hydrogels can mimic several features of the cell native microenvironment and have been widely used as synthetic extracellular matrices (ECMs) in tissue engineering and regenerative medicine (TERM). However, some applications have specifications that hydrogels cannot efficiently fulfill on their own. Incorporating reinforcing structures like fibrous scaffolds or particles into hydrogels, as hybrid systems, is a promising strategy to improve their functionality. We describe recent advances in the fabrication and application of these hybrid systems, where structural properties and stimuli responsiveness of hydrogels are enhanced while their ECM-like features are preserved. Furthermore, we discuss how these systems can contribute to the development of more complex tissue engineered structures in the rapidly evolving field of TERM.",
keywords = "MESENCHYMAL STEM-CELLS, SKELETAL-MUSCLE-TISSUE, CARBON NANOTUBE, EXTRACELLULAR-MATRIX, REGENERATIVE MEDICINE, COMPOSITE SCAFFOLDS, COLLAGEN HYDROGELS, VASCULARIZATION, BIOMATERIALS, STRATEGIES",
author = "Neves, {Sara C.} and Lorenzo Moroni and Barrias, {Cristina C.} and Granja, {Pedro L.}",
note = "Funding Information: This work was supported by Norte Portugal Regional Operational Programme (NORTE2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF) project Norte-01-0145-FEDER-000012 “Structured program on bioengineered therapies for infectious diseases and tissue regeneration”, through COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (POCI) Portugal 2020 and Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT) in the framework of the projects “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274), and “SKINPRINT” (POCI-01-0145-FEDER-016629 and PTDC/BBB-ECT/2145/2014), C.C. Barrias research position FCT Investigator (IF/00296/2015), S.C. Neves doctoral grant SFRH/BD/76995/2011 and research grant PTDC/BBB-ECT/2145/2014. Funding Information: This work was supported by Norte Portugal Regional Operational Programme (NORTE2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF) project Norte-01-0145-FEDER-000012 ?Structured program on bioengineered therapies for infectious diseases and tissue regeneration?, through COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (POCI) Portugal 2020 and Funda??o para a Ci?ncia e a Tecnologia (FCT) in the framework of the projects ?Institute for Research and Innovation in Health Sciences? (POCI-01-0145-FEDER-007274), and ?SKINPRINT? (POCI-01-0145-FEDER-016629 and PTDC/BBB-ECT/2145/2014), C.C. Barrias research position FCT Investigator (IF/00296/2015), S.C. Neves doctoral grant SFRH/BD/76995/2011 and research grant PTDC/BBB-ECT/2145/2014. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = mar,
doi = "10.1016/j.tibtech.2019.09.004",
language = "English",
volume = "38",
pages = "292--315",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Science",
number = "3",
}