Leveling Up Hydrogels: Hybrid Systems in Tissue Engineering

Sara C. Neves, Lorenzo Moroni*, Cristina C. Barrias, Pedro L. Granja

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

35 Citations (Web of Science)
242 Downloads (Pure)

Abstract

Hydrogels can mimic several features of the cell native microenvironment and have been widely used as synthetic extracellular matrices (ECMs) in tissue engineering and regenerative medicine (TERM). However, some applications have specifications that hydrogels cannot efficiently fulfill on their own. Incorporating reinforcing structures like fibrous scaffolds or particles into hydrogels, as hybrid systems, is a promising strategy to improve their functionality. We describe recent advances in the fabrication and application of these hybrid systems, where structural properties and stimuli responsiveness of hydrogels are enhanced while their ECM-like features are preserved. Furthermore, we discuss how these systems can contribute to the development of more complex tissue engineered structures in the rapidly evolving field of TERM.

Original languageEnglish
Pages (from-to)292-315
Number of pages24
JournalTrends in Biotechnology
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • MESENCHYMAL STEM-CELLS
  • SKELETAL-MUSCLE-TISSUE
  • CARBON NANOTUBE
  • EXTRACELLULAR-MATRIX
  • REGENERATIVE MEDICINE
  • COMPOSITE SCAFFOLDS
  • COLLAGEN HYDROGELS
  • VASCULARIZATION
  • BIOMATERIALS
  • STRATEGIES

Cite this