Lessons from ECLIPSE: a review of COPD biomarkers

R. Faner; R. Tal-Singer; J.H. Riley; B. Celli; J. Vestbo; W. MacNee; P. Bakke; P.M.A. Calverley; H. Coxson; C. Crim; L.D. Edwards; N. Locantore; D.A. Lomas; B.E. Miller; S.I. Rennard; E.F.M. Wouters; J.C. Yates; E.K. Silverman; the ECLIPSE Study Investigators; A. Agusti

doi:10.1136/thoraxjnl-2013-204778

Lessons from ECLIPSE: a review of COPD biomarkers

R. Faner, R. Tal-Singer, J.H. Riley, B. Celli, J. Vestbo, W. MacNee, P. Bakke, P.M.A. Calverley, H. Coxson, C. Crim, L.D. Edwards, N. Locantore, D.A. Lomas, B.E. Miller, S.I. Rennard, E.F.M. Wouters, J.C. Yates, E.K. Silverman, the ECLIPSE Study Investigators, A. Agusti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.

Original language	English
Pages (from-to)	666-672
Number of pages	7
Journal	Thorax
Volume	69
Issue number	7
Early online date	5 Dec 2013
DOIs	https://doi.org/10.1136/thoraxjnl-2013-204778
Publication status	Published - Jul 2014

Keywords

OBSTRUCTIVE PULMONARY-DISEASE
GENOME-WIDE ASSOCIATION
SURFACTANT PROTEIN-D
SYSTEMIC INFLAMMATION
SUSCEPTIBILITY LOCUS
SPUTUM NEUTROPHILS
BLOOD BIOMARKERS
LUNG-FUNCTION
EMPHYSEMA
COHORT

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10.1136/thoraxjnl-2013-204778

Cite this

Faner, R., Tal-Singer, R., Riley, J. H., Celli, B., Vestbo, J., MacNee, W., Bakke, P., Calverley, P. M. A., Coxson, H., Crim, C., Edwards, L. D., Locantore, N., Lomas, D. A., Miller, B. E., Rennard, S. I., Wouters, E. F. M., Yates, J. C., Silverman, E. K., ECLIPSE Study Investigators, T., & Agusti, A. (2014). Lessons from ECLIPSE: a review of COPD biomarkers. Thorax, 69(7), 666-672. https://doi.org/10.1136/thoraxjnl-2013-204778

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abstract = "The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.",

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Faner, R, Tal-Singer, R, Riley, JH, Celli, B, Vestbo, J, MacNee, W, Bakke, P, Calverley, PMA, Coxson, H, Crim, C, Edwards, LD, Locantore, N, Lomas, DA, Miller, BE, Rennard, SI, Wouters, EFM, Yates, JC, Silverman, EK, ECLIPSE Study Investigators, T & Agusti, A 2014, 'Lessons from ECLIPSE: a review of COPD biomarkers', Thorax, vol. 69, no. 7, pp. 666-672. https://doi.org/10.1136/thoraxjnl-2013-204778

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AU - Vestbo, J.

AU - MacNee, W.

AU - Bakke, P.

AU - Calverley, P.M.A.

AU - Coxson, H.

AU - Crim, C.

AU - Edwards, L.D.

AU - Locantore, N.

AU - Lomas, D.A.

AU - Miller, B.E.

AU - Rennard, S.I.

AU - Wouters, E.F.M.

AU - Yates, J.C.

AU - Silverman, E.K.

AU - ECLIPSE Study Investigators, the

AU - Agusti, A.

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AB - The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.

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KW - GENOME-WIDE ASSOCIATION

KW - SURFACTANT PROTEIN-D

KW - SYSTEMIC INFLAMMATION

KW - SUSCEPTIBILITY LOCUS

KW - SPUTUM NEUTROPHILS

KW - BLOOD BIOMARKERS

KW - LUNG-FUNCTION

KW - EMPHYSEMA

KW - COHORT

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DO - 10.1136/thoraxjnl-2013-204778

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SN - 0040-6376

VL - 69

SP - 666

EP - 672

JO - Thorax

JF - Thorax

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ER -