Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.

Isabelle C. Van Gelder; Hessel F. Groenveld; Harry J. G. M. Crijns; Ype S. Tuininga; Jan G. P. Tijssen; A. Marco Alings; Hans L. Hillege; Johanna A. Bergsma-Kadijk; Jan H. Cornel; Otto Kamp; Raymond Tukkie; Hans A. Bosker; Dirk J. van Veldhuisen; Maarten P. Van den Berg

doi:10.1056/NEJMoa1001337

Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.

Isabelle C. Van Gelder^*
, Hessel F. Groenveld
, Harry J. G. M. Crijns
, Ype S. Tuininga
, Jan G. P. Tijssen
, A. Marco Alings
, Hans L. Hillege
, Johanna A. Bergsma-Kadijk
, Jan H. Cornel
, Otto Kamp
, Raymond Tukkie
, Hans A. Bosker
, Dirk J. van Veldhuisen
, Maarten P. Van den Berg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. Methods: We randomly assigned 614 patients with permanent atrial fibrillation to undergo a lenient rate-control strategy (resting heart rate

Original language	English
Pages (from-to)	1363-1373
Number of pages	11
Journal	New England Journal of Medicine
Volume	362
Issue number	15
DOIs	https://doi.org/10.1056/NEJMoa1001337
Publication status	Published - 15 Apr 2010

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10.1056/NEJMoa1001337

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Van Gelder, I. C., Groenveld, H. F., Crijns, H. J. G. M., Tuininga, Y. S., Tijssen, J. G. P., Alings, A. M., Hillege, H. L., Bergsma-Kadijk, J. A., Cornel, J. H., Kamp, O., Tukkie, R., Bosker, H. A., van Veldhuisen, D. J., & Van den Berg, M. P. (2010). Lenient versus Strict Rate Control in Patients with Atrial Fibrillation. New England Journal of Medicine, 362(15), 1363-1373. https://doi.org/10.1056/NEJMoa1001337

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title = "Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.",

abstract = "Background: Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. Methods: We randomly assigned 614 patients with permanent atrial fibrillation to undergo a lenient rate-control strategy (resting heart rate ",

author = "\{Van Gelder\}, \{Isabelle C.\} and Groenveld, \{Hessel F.\} and Crijns, \{Harry J. G. M.\} and Tuininga, \{Ype S.\} and Tijssen, \{Jan G. P.\} and Alings, \{A. Marco\} and Hillege, \{Hans L.\} and Bergsma-Kadijk, \{Johanna A.\} and Cornel, \{Jan H.\} and Otto Kamp and Raymond Tukkie and Bosker, \{Hans A.\} and \{van Veldhuisen\}, \{Dirk J.\} and \{Van den Berg\}, \{Maarten P.\}",

year = "2010",

month = apr,

day = "15",

doi = "10.1056/NEJMoa1001337",

language = "English",

volume = "362",

pages = "1363--1373",

journal = "New England Journal of Medicine",

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Van Gelder, IC, Groenveld, HF, Crijns, HJGM, Tuininga, YS, Tijssen, JGP, Alings, AM, Hillege, HL, Bergsma-Kadijk, JA, Cornel, JH, Kamp, O, Tukkie, R, Bosker, HA, van Veldhuisen, DJ & Van den Berg, MP 2010, 'Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.', New England Journal of Medicine, vol. 362, no. 15, pp. 1363-1373. https://doi.org/10.1056/NEJMoa1001337

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T1 - Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.

AU - Van Gelder, Isabelle C.

AU - Groenveld, Hessel F.

AU - Crijns, Harry J. G. M.

AU - Tuininga, Ype S.

AU - Tijssen, Jan G. P.

AU - Alings, A. Marco

AU - Hillege, Hans L.

AU - Bergsma-Kadijk, Johanna A.

AU - Cornel, Jan H.

AU - Kamp, Otto

AU - Tukkie, Raymond

AU - Bosker, Hans A.

AU - van Veldhuisen, Dirk J.

AU - Van den Berg, Maarten P.

PY - 2010/4/15

Y1 - 2010/4/15

N2 - Background: Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. Methods: We randomly assigned 614 patients with permanent atrial fibrillation to undergo a lenient rate-control strategy (resting heart rate

AB - Background: Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. Methods: We randomly assigned 614 patients with permanent atrial fibrillation to undergo a lenient rate-control strategy (resting heart rate

U2 - 10.1056/NEJMoa1001337

DO - 10.1056/NEJMoa1001337

M3 - Article

C2 - 20231232

SN - 0028-4793

VL - 362

SP - 1363

EP - 1373

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 15

ER -

Lenient versus Strict Rate Control in Patients with Atrial Fibrillation.

Abstract

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