Left Ventricular Three-Dimensional Quadripolar Lead Acute Clinical Study: The LILAC Study

Francois Philippon*, Lili Liu, Jeffrey Wing-Hong Fung, Jean-Claude Deharo, Frederic Anselme, Peter Paul Delnoy, Harry Crijns, Carlos A. Morillo, Andrew D. Krahn, Klaus Gutleben, Julien Delumeau, Franck Molin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Aims This multicenter acute clinical study was designed to verify novel three-dimensional (3D) quadripolar lead designs that can achieve 2.5 V average pacing capture threshold (PCT) not only at the apex, but also at the base of the left ventricle with phrenic nerve stimulation (PNS) avoidance for cardiac resynchronization. MethodsDuring the implant procedure, up to two different left ventricular investigational leads were introduced and tested in the same target coronary vein based on the coronary sinus venogram in a wedged and unwedged position. Adverse events were collected in 30 days following the procedure. ResultsEighty-seven leads were tested in 50 patients. When the best performing spiral electrode was chosen from each lead testing, the average of the best PCT on spiral in a wedged position was similar to the unwedged position (1.7 1.5 V vs 1.9 +/- 1.5 V, P = ns) and was similar to the wedged tip electrode average PCT (1.7 +/- 1.5 V vs 1.6 +/- 1.6 V, P = ns). In the majority of patients (89-96%), pacing was achievable in a mid-basal ventricular location without PNS. ConclusionsThis acute study demonstrated that a 3D quadripolar spiral lead design can achieve acceptable PCTs and avoid PNS without repositioning the lead at implant in the vast majority of patients. It also demonstrated that this lead design can achieve mid-basal ventricular stimulation with low PCT and good acute stability.
Original languageEnglish
Pages (from-to)438-447
JournalPacing and Clinical Electrophysiology
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2015

Keywords

  • quadripolar leads
  • cardiac resynchronization
  • lead design

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