Left Ventricular Structure and Function in Relation to Steroid Biosynthesis Genes in a White Population

Yu Jin; Tatiana Kuznetsova; Lorena Citterio; Lutgarde Thijs; Elisabetta Messaggio; Nunzia Casamassima; Paolo Manunta; Robert Fagard; Giuseppe Bianchi; Jan A. Staessen

doi:10.1038/ajh.2012.69

Left Ventricular Structure and Function in Relation to Steroid Biosynthesis Genes in a White Population

Yu Jin, Tatiana Kuznetsova, Lorena Citterio, Lutgarde Thijs, Elisabetta Messaggio, Nunzia Casamassima, Paolo Manunta, Robert Fagard, Giuseppe Bianchi, Jan A. Staessen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Web of Science)

Abstract

BACKGROUND Both endogenous ouabain (EO) and aldosterone are steroid hormones which might play a role in the pathogenesis of left ventricular (LV) hypertrophy and cardiac remodeling. Cholesterol side-chain cleavage enzyme (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis. METHODS We investigated in 532 individuals (mean age, 50.3 years; 51.5% women) randomly recruited from a white European population whether LV structure and function were related to genetic variations in CYP11A1 and HSD3B1. We measured LV structure by conventional echocardiography and LV diastolic function by Doppler imaging of the transmitral blood flow and the mitral annular movement. We genotyped tag single nucleotide polymorphisms (SNPs) rs2279357, rs11638442 and rs2073475 in CYP11A1, and rs2236780, rs3765945, and rs6203 in HSD3B1. RESULTS While adjusting for covariables and accounting for family clusters, LV mass index decreased (P = 0.07). CONCLUSIONS Pending confirmation in other studies, LV mass and LV diastolic function seem to be related to genetic variation in the steroid biosynthesis.

Original language	English
Pages (from-to)	986-993
Journal	American Journal of Hypertension
Volume	25
Issue number	9
DOIs	https://doi.org/10.1038/ajh.2012.69
Publication status	Published - Sep 2012

Keywords

blood pressure
epidemiology
genetic association study
hypertension
left ventricle
steroid hormone biosynthesis

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10.1038/ajh.2012.69

Cite this

@article{5117873dd0ee461f9176ea57028a14b6,

title = "Left Ventricular Structure and Function in Relation to Steroid Biosynthesis Genes in a White Population",

abstract = "BACKGROUND Both endogenous ouabain (EO) and aldosterone are steroid hormones which might play a role in the pathogenesis of left ventricular (LV) hypertrophy and cardiac remodeling. Cholesterol side-chain cleavage enzyme (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis. METHODS We investigated in 532 individuals (mean age, 50.3 years; 51.5% women) randomly recruited from a white European population whether LV structure and function were related to genetic variations in CYP11A1 and HSD3B1. We measured LV structure by conventional echocardiography and LV diastolic function by Doppler imaging of the transmitral blood flow and the mitral annular movement. We genotyped tag single nucleotide polymorphisms (SNPs) rs2279357, rs11638442 and rs2073475 in CYP11A1, and rs2236780, rs3765945, and rs6203 in HSD3B1. RESULTS While adjusting for covariables and accounting for family clusters, LV mass index decreased (P = 0.07). CONCLUSIONS Pending confirmation in other studies, LV mass and LV diastolic function seem to be related to genetic variation in the steroid biosynthesis.",

keywords = "blood pressure, epidemiology, genetic association study, hypertension, left ventricle, steroid hormone biosynthesis",

author = "Yu Jin and Tatiana Kuznetsova and Lorena Citterio and Lutgarde Thijs and Elisabetta Messaggio and Nunzia Casamassima and Paolo Manunta and Robert Fagard and Giuseppe Bianchi and Staessen, {Jan A.}",

year = "2012",

month = sep,

doi = "10.1038/ajh.2012.69",

language = "English",

volume = "25",

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issn = "0895-7061",

publisher = "Oxford University Press",

number = "9",

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TY - JOUR

T1 - Left Ventricular Structure and Function in Relation to Steroid Biosynthesis Genes in a White Population

AU - Jin, Yu

AU - Kuznetsova, Tatiana

AU - Citterio, Lorena

AU - Thijs, Lutgarde

AU - Messaggio, Elisabetta

AU - Casamassima, Nunzia

AU - Manunta, Paolo

AU - Fagard, Robert

AU - Bianchi, Giuseppe

AU - Staessen, Jan A.

PY - 2012/9

Y1 - 2012/9

N2 - BACKGROUND Both endogenous ouabain (EO) and aldosterone are steroid hormones which might play a role in the pathogenesis of left ventricular (LV) hypertrophy and cardiac remodeling. Cholesterol side-chain cleavage enzyme (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis. METHODS We investigated in 532 individuals (mean age, 50.3 years; 51.5% women) randomly recruited from a white European population whether LV structure and function were related to genetic variations in CYP11A1 and HSD3B1. We measured LV structure by conventional echocardiography and LV diastolic function by Doppler imaging of the transmitral blood flow and the mitral annular movement. We genotyped tag single nucleotide polymorphisms (SNPs) rs2279357, rs11638442 and rs2073475 in CYP11A1, and rs2236780, rs3765945, and rs6203 in HSD3B1. RESULTS While adjusting for covariables and accounting for family clusters, LV mass index decreased (P = 0.07). CONCLUSIONS Pending confirmation in other studies, LV mass and LV diastolic function seem to be related to genetic variation in the steroid biosynthesis.

AB - BACKGROUND Both endogenous ouabain (EO) and aldosterone are steroid hormones which might play a role in the pathogenesis of left ventricular (LV) hypertrophy and cardiac remodeling. Cholesterol side-chain cleavage enzyme (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis. METHODS We investigated in 532 individuals (mean age, 50.3 years; 51.5% women) randomly recruited from a white European population whether LV structure and function were related to genetic variations in CYP11A1 and HSD3B1. We measured LV structure by conventional echocardiography and LV diastolic function by Doppler imaging of the transmitral blood flow and the mitral annular movement. We genotyped tag single nucleotide polymorphisms (SNPs) rs2279357, rs11638442 and rs2073475 in CYP11A1, and rs2236780, rs3765945, and rs6203 in HSD3B1. RESULTS While adjusting for covariables and accounting for family clusters, LV mass index decreased (P = 0.07). CONCLUSIONS Pending confirmation in other studies, LV mass and LV diastolic function seem to be related to genetic variation in the steroid biosynthesis.

KW - blood pressure

KW - epidemiology

KW - genetic association study

KW - hypertension

KW - left ventricle

KW - steroid hormone biosynthesis

U2 - 10.1038/ajh.2012.69

DO - 10.1038/ajh.2012.69

M3 - Article

C2 - 22673022

VL - 25

SP - 986

EP - 993

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

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ER -