Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study

Raffaele Altara; Yu-Mei Gu; Harry A. J. Struijker-Boudier; Lutgarde Thijs; Jan A. Staessen; W. Matthijs Blankesteijn

doi:10.1371/journal.pone.0141394

Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study

Raffaele Altara
, Yu-Mei Gu
, Harry A. J. Struijker-Boudier
, Lutgarde Thijs
, Jan A. Staessen
, W. Matthijs Blankesteijn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Detecting left ventricular (LV) dysfunction at an early stage is key in addressing the heart failure epidemic. In proteome profiling experiments in mice subjected either to aortic banding or sham, the circulating CXCR3 ligands monokine induced by interferon-gamma (MIG) and interferon-gamma inducible protein 10 (IP10) were 5 to 40 fold up-regulated at eight weeks. We assessed the diagnostic value of circulating NT-pro BNP and CXCR3 ligands (MIG, IP10, Interferon-inducible T-cell alpha chemo-attractant [I-TAC]) in patients with hypertension (>= 140/90 mm Hg) associated with subclinical (n = 19) or symptomatic (n = 16) diastolic LV dysfunction on echocardiography and healthy controls. NT-pro BNP, MIG, IP10, I-TAC all increased (p

Original language	English
Article number	e0141394
Journal	PLOS ONE
Volume	10
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0141394
Publication status	Published - 27 Oct 2015

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10.1371/journal.pone.0141394Licence: CC BY

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title = "Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study",

abstract = "Detecting left ventricular (LV) dysfunction at an early stage is key in addressing the heart failure epidemic. In proteome profiling experiments in mice subjected either to aortic banding or sham, the circulating CXCR3 ligands monokine induced by interferon-gamma (MIG) and interferon-gamma inducible protein 10 (IP10) were 5 to 40 fold up-regulated at eight weeks. We assessed the diagnostic value of circulating NT-pro BNP and CXCR3 ligands (MIG, IP10, Interferon-inducible T-cell alpha chemo-attractant [I-TAC]) in patients with hypertension (>= 140/90 mm Hg) associated with subclinical (n = 19) or symptomatic (n = 16) diastolic LV dysfunction on echocardiography and healthy controls. NT-pro BNP, MIG, IP10, I-TAC all increased (p ",

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AU - Gu, Yu-Mei

AU - Struijker-Boudier, Harry A. J.

AU - Thijs, Lutgarde

AU - Staessen, Jan A.

AU - Blankesteijn, W. Matthijs

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Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study

Abstract

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