TY - JOUR
T1 - Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study
AU - Altara, Raffaele
AU - Gu, Yu-Mei
AU - Struijker-Boudier, Harry A. J.
AU - Thijs, Lutgarde
AU - Staessen, Jan A.
AU - Blankesteijn, W. Matthijs
PY - 2015/10/27
Y1 - 2015/10/27
N2 - Detecting left ventricular (LV) dysfunction at an early stage is key in addressing the heart failure epidemic. In proteome profiling experiments in mice subjected either to aortic banding or sham, the circulating CXCR3 ligands monokine induced by interferon-gamma (MIG) and interferon-gamma inducible protein 10 (IP10) were 5 to 40 fold up-regulated at eight weeks. We assessed the diagnostic value of circulating NT-pro BNP and CXCR3 ligands (MIG, IP10, Interferon-inducible T-cell alpha chemo-attractant [I-TAC]) in patients with hypertension (>= 140/90 mm Hg) associated with subclinical (n = 19) or symptomatic (n = 16) diastolic LV dysfunction on echocardiography and healthy controls. NT-pro BNP, MIG, IP10, I-TAC all increased (p
AB - Detecting left ventricular (LV) dysfunction at an early stage is key in addressing the heart failure epidemic. In proteome profiling experiments in mice subjected either to aortic banding or sham, the circulating CXCR3 ligands monokine induced by interferon-gamma (MIG) and interferon-gamma inducible protein 10 (IP10) were 5 to 40 fold up-regulated at eight weeks. We assessed the diagnostic value of circulating NT-pro BNP and CXCR3 ligands (MIG, IP10, Interferon-inducible T-cell alpha chemo-attractant [I-TAC]) in patients with hypertension (>= 140/90 mm Hg) associated with subclinical (n = 19) or symptomatic (n = 16) diastolic LV dysfunction on echocardiography and healthy controls. NT-pro BNP, MIG, IP10, I-TAC all increased (p
U2 - 10.1371/journal.pone.0141394
DO - 10.1371/journal.pone.0141394
M3 - Article
C2 - 26506526
SN - 1932-6203
VL - 10
JO - PLOS ONE
JF - PLOS ONE
IS - 10
M1 - e0141394
ER -