Left bundle branch pacing compared to left ventricular septal myocardial pacing increases interventricular dyssynchrony but accelerates left ventricular lateral wall depolarization

Karol Curila*, Pavel Jurak, Marek Jastrzebski, Frits Prinzen, Petr Waldauf, Josef Halamek, Kevin Vernooy, Radovan Smisek, Jakub Karch, Filip Plesinger, Pawel Moskal, Marketa Susankova, Lucie Znojilova, Luuk Heckman, Ivo Viscor, Vlastimil Vondra, Pavel Leinveber, Pavel Osmancik

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND Nonselective His-bundle pacing (nsHBp), nonselective left bundle branch pacing (nsLBBp), and left ventricular septal myocardial pacing (LVSP) are recognized as physiological pacing tech niques.

OBJECTIVE The purpose of this study was to compare differences in ventricular depolarization between these techniques using ultrahigh-frequency electrocardiography (UHF-ECG).

METHODS In patients with bradycardia, nsHBp, nsLBBp (confirmed concomitant left bundle branch [LBB] and myocardial capture), and LVSP (pacing in left ventricular [LV] septal position without proven LBB capture) were performed. Timings of ventricular activations in precordial leads were displayed using UHF-ECG, and electrical dyssynchrony (e-DYS) was calculated as the difference between the first and last activation. Duration of local depolarization (Vd) was determined as width of the UHF-QRS complex at 50% of its amplitude.

RESULTS In 68 patients, data were collected during nsLBBp (35), LVSP (96), and nsHBp (55). nsLBBp resulted in larger e-DYS than did LVSP and nsH Bp [- 24 ms (-28;-19) vs -12 ms (-16;-9) vs 10 ms (7;14), respectively; P

CONCLUSION nslbbp preserves physiological LV depolarization but increases interventricular electrical dyssynchrony. LV lateral wall depolarization during LVSP is prolonged, but interventricular synchrony is preserved.

Original languageEnglish
Pages (from-to)1281-1289
Number of pages9
JournalHeart Rhythm
Issue number8
Publication statusPublished - Aug 2021


  • Depolarization duration
  • Dyssynchrony
  • His-bundle pacing
  • Left bundle branch pacing
  • Left ventricular septal myocardial pacing
  • Ultra-high-frequency electrocardiography

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