Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

Patrick Houthuizen; Leen A. F. M. Van Garsse; Thomas T. Poels; Peter de Jaegere; Robert M. A. van der Boon; Ben M. Swinkels; Jurrien M. ten Berg; Frank van der Kley; Martin J. Schalij; Jan, Jr. Baan; Ricardo Cocchieri; Guus R. G. Brueren; Albert H. M. van Straten; Peter den Heijer; Mohamed Bentala; Vincent van Ommen; Jolanda Kluin; Pieter R. Stella; Martin H. Prins; Jos G. Maessen; Frits W. Prinzen

doi:10.1161/CIRCULATIONAHA.112.101055

Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

Patrick Houthuizen, Leen A. F. M. Van Garsse, Thomas T. Poels, Peter de Jaegere, Robert M. A. van der Boon, Ben M. Swinkels, Jurrien M. ten Berg, Frank van der Kley, Martin J. Schalij, Jan, Jr. Baan, Ricardo Cocchieri, Guus R. G. Brueren, Albert H. M. van Straten, Peter den Heijer, Mohamed Bentala, Vincent van Ommen, Jolanda Kluin, Pieter R. Stella, Martin H. Prins, Jos G. MaessenFrits W. Prinzen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction

Original language	English
Pages (from-to)	720-728
Journal	Circulation
Volume	126
Issue number	6
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.112.101055
Publication status	Published - 7 Aug 2012

Keywords

conduction
heart failure
left bundle-branch block
mortality
transcatheter aortic valve implantation

Access to Document

10.1161/CIRCULATIONAHA.112.101055

Cite this

Houthuizen, P., Van Garsse, L. A. F. M., Poels, T. T., de Jaegere, P., van der Boon, R. M. A., Swinkels, B. M., ten Berg, J. M., van der Kley, F., Schalij, M. J., Baan, J. J., Cocchieri, R., Brueren, G. R. G., van Straten, A. H. M., den Heijer, P., Bentala, M., van Ommen, V., Kluin, J., Stella, P. R., Prins, M. H., ... Prinzen, F. W. (2012). Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. Circulation, 126(6), 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

@article{8772616174444656a10fc2fb2ac1856f,

title = "Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death",

abstract = "Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction ",

keywords = "conduction, heart failure, left bundle-branch block, mortality, transcatheter aortic valve implantation",

author = "Patrick Houthuizen and {Van Garsse}, {Leen A. F. M.} and Poels, {Thomas T.} and {de Jaegere}, Peter and {van der Boon}, {Robert M. A.} and Swinkels, {Ben M.} and {ten Berg}, {Jurrien M.} and {van der Kley}, Frank and Schalij, {Martin J.} and Baan, {Jan, Jr.} and Ricardo Cocchieri and Brueren, {Guus R. G.} and {van Straten}, {Albert H. M.} and {den Heijer}, Peter and Mohamed Bentala and {van Ommen}, Vincent and Jolanda Kluin and Stella, {Pieter R.} and Prins, {Martin H.} and Maessen, {Jos G.} and Prinzen, {Frits W.}",

year = "2012",

month = aug,

day = "7",

doi = "10.1161/CIRCULATIONAHA.112.101055",

language = "English",

volume = "126",

pages = "720--728",

journal = "Circulation",

issn = "0009-7322",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "6",

}

Houthuizen, P, Van Garsse, LAFM, Poels, TT, de Jaegere, P, van der Boon, RMA, Swinkels, BM, ten Berg, JM, van der Kley, F, Schalij, MJ, Baan, JJ, Cocchieri, R, Brueren, GRG, van Straten, AHM, den Heijer, P, Bentala, M, van Ommen, V, Kluin, J, Stella, PR, Prins, MH, Maessen, JG & Prinzen, FW 2012, 'Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death', Circulation, vol. 126, no. 6, pp. 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

TY - JOUR

T1 - Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

AU - Houthuizen, Patrick

AU - Van Garsse, Leen A. F. M.

AU - Poels, Thomas T.

AU - de Jaegere, Peter

AU - van der Boon, Robert M. A.

AU - Swinkels, Ben M.

AU - ten Berg, Jurrien M.

AU - van der Kley, Frank

AU - Schalij, Martin J.

AU - Baan, Jan, Jr.

AU - Cocchieri, Ricardo

AU - Brueren, Guus R. G.

AU - van Straten, Albert H. M.

AU - den Heijer, Peter

AU - Bentala, Mohamed

AU - van Ommen, Vincent

AU - Kluin, Jolanda

AU - Stella, Pieter R.

AU - Prins, Martin H.

AU - Maessen, Jos G.

AU - Prinzen, Frits W.

PY - 2012/8/7

Y1 - 2012/8/7

N2 - Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction

AB - Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction

KW - conduction

KW - heart failure

KW - left bundle-branch block

KW - mortality

KW - transcatheter aortic valve implantation

U2 - 10.1161/CIRCULATIONAHA.112.101055

DO - 10.1161/CIRCULATIONAHA.112.101055

M3 - Article

C2 - 22791865

SN - 0009-7322

VL - 126

SP - 720

EP - 728

JO - Circulation

JF - Circulation

IS - 6

ER -