Learning curve predictors for minimally invasive mitral valve surgery; how far should the rabbit hole go?

Aleksander Dokollari*, Matteo Cameli, Didar-Karan S. Kalra, Mohammad B. Pervez, Michalis Demosthenous, Marjela Pernoci, Daniel Bonneau, David Latter, Sandro Gelsomino, Gianfranco Lisi, Bobby Yanagawa, Subodh Verma, Gianluigi Bisleri, Massimo Bonacchi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)


Objective To analyze predictors that influence the learning curve of minimally invasive mitral valve surgery (MIMVS). Methods Patients who underwent MIMVS between March 2010 to March 2015 were retrospectively analyzed. Predictive factors that influence the learning curve were analyzed. Results One hundred and five patients were included in the analysis. Cardiopulmonary bypass (CPB) time in minutes was 158.72 +/- 40.98 and the aortic cross-clamp (ACC) time in minutes was 114.48 +/- 27.29. There were three operative mortalities, one stroke and five >2+ mitral regurgitation. ACC time in minutes was higher in the low logistic Euroscore II (LES) group (LES <5% = 118.42 +/- 27.94) versus (LES >= 5 = 88.66 +/- 22.26),P <.05 while creatinine clearance in mu mol/L was higher in the LES <5% group (LES <5% = 84.32 +/- 33.7) versus (LES >= 5% = 41.66 +/- 17.14), (P <.05). One patient from each group required chest tube insertion for pleural effusionP <.05. The cumulative sum analysis (CUSUM) for the first 25 patients had CPB and ACC times that reached the upper limits. Between 25 to 64 patients the curve remained stable while with the introduction of reoperations and complex surgical procedures the CUSUM reached the upper limits. Conclusions The learning curve is affected by many factors but this should not desist surgeons from approaching this technique. The introduction of high-risk patients in clinical practice should be carefully measured based on surgeon experience.

Original languageEnglish
Pages (from-to)2934-2942
Number of pages9
JournalJournal of Cardiac Surgery
Issue number11
Early online date13 Aug 2020
Publication statusPublished - Nov 2020


  • BMI
  • learning curve
  • logistic Euroscore II
  • minimally invasive mitral
  • predictive factors
  • redo surgeries

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