Late-onset thyrotoxicosis after the cessation of amiodarone

Melissa E. Middeldorp; Adrian D. Elliott; Celine Gallagher; Dominik Linz; Jeroen M. L. Hendriks; Rajiv Mahajan; Dennis H. Lau; Prashanthan Sanders

doi:10.1016/j.ipej.2020.07.006

Late-onset thyrotoxicosis after the cessation of amiodarone

Melissa E. Middeldorp, Adrian D. Elliott, Celine Gallagher, Dominik Linz, Jeroen M. L. Hendriks, Rajiv Mahajan, Dennis H. Lau, Prashanthan Sanders

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: Amiodarone is a highly effective antiarrhythmic-drug with well recognized toxic side-effects. The effects of the drug late in patients with atrial fibrillation (AF) is not well described. Methods and results: We present a single centre prospectively collected series of patients with thyrotoxicosis occurring late after the cessation of amiodarone. Between 2006 and 2018, 8 patients were identified with amiodarone induced thyrotoxicosis (AIT). Amiodarone was prescribed for AF in 7 patients and ventricular tachycardia in 1 patient. Mean duration of therapy was 329 [42–1092] days, mean dose of 200 ± 103.5 mg/day. Amiodarone use was short term (

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	Indian pacing and electrophysiology journal
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.ipej.2020.07.006
Publication status	Published - 2020
Externally published	Yes

Keywords

Amiodarone Atrial fibrillation Drug toxicity Thyrotoxicosis Ventricular arrhythmia

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10.1016/j.ipej.2020.07.006Licence: CC BY-NC-ND

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title = "Late-onset thyrotoxicosis after the cessation of amiodarone",

abstract = "Introduction: Amiodarone is a highly effective antiarrhythmic-drug with well recognized toxic side-effects. The effects of the drug late in patients with atrial fibrillation (AF) is not well described. Methods and results: We present a single centre prospectively collected series of patients with thyrotoxicosis occurring late after the cessation of amiodarone. Between 2006 and 2018, 8 patients were identified with amiodarone induced thyrotoxicosis (AIT). Amiodarone was prescribed for AF in 7 patients and ventricular tachycardia in 1 patient. Mean duration of therapy was 329 [42–1092] days, mean dose of 200 ± 103.5 mg/day. Amiodarone use was short term (",

keywords = "Amiodarone Atrial fibrillation Drug toxicity Thyrotoxicosis Ventricular arrhythmia",

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T1 - Late-onset thyrotoxicosis after the cessation of amiodarone

AU - Middeldorp, Melissa E.

AU - Elliott, Adrian D.

AU - Gallagher, Celine

AU - Linz, Dominik

AU - Hendriks, Jeroen M. L.

AU - Mahajan, Rajiv

AU - Lau, Dennis H.

AU - Sanders, Prashanthan

N1 - Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) 10.1016/j.ipej.2020.07.006

PY - 2020

Y1 - 2020

N2 - Introduction: Amiodarone is a highly effective antiarrhythmic-drug with well recognized toxic side-effects. The effects of the drug late in patients with atrial fibrillation (AF) is not well described. Methods and results: We present a single centre prospectively collected series of patients with thyrotoxicosis occurring late after the cessation of amiodarone. Between 2006 and 2018, 8 patients were identified with amiodarone induced thyrotoxicosis (AIT). Amiodarone was prescribed for AF in 7 patients and ventricular tachycardia in 1 patient. Mean duration of therapy was 329 [42–1092] days, mean dose of 200 ± 103.5 mg/day. Amiodarone use was short term (

AB - Introduction: Amiodarone is a highly effective antiarrhythmic-drug with well recognized toxic side-effects. The effects of the drug late in patients with atrial fibrillation (AF) is not well described. Methods and results: We present a single centre prospectively collected series of patients with thyrotoxicosis occurring late after the cessation of amiodarone. Between 2006 and 2018, 8 patients were identified with amiodarone induced thyrotoxicosis (AIT). Amiodarone was prescribed for AF in 7 patients and ventricular tachycardia in 1 patient. Mean duration of therapy was 329 [42–1092] days, mean dose of 200 ± 103.5 mg/day. Amiodarone use was short term (

KW - Amiodarone Atrial fibrillation Drug toxicity Thyrotoxicosis Ventricular arrhythmia

U2 - 10.1016/j.ipej.2020.07.006

DO - 10.1016/j.ipej.2020.07.006

M3 - Article

SN - 0972-6292

VL - 20

SP - 265

EP - 268

JO - Indian pacing and electrophysiology journal

JF - Indian pacing and electrophysiology journal

IS - 6

ER -

Late-onset thyrotoxicosis after the cessation of amiodarone

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