Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

Daniel J. C. Berkhout; Britt J. van Keulen; Hendrik J. Niemarkt; Jet R. Bessem; Willem P. de Boode; Veerle Cossey; Neil Hoogenes; Christiaan V. Hulzebos; Ellen Klaver; Peter Andriessen; Anton H. van Kaam; Boris W. Kramer; Richard A. van Lingen; Aaron Schouten; Johannes B. van Goudoever; Daniel C. Vijlbrief; Mirjam M. van Weissenbruch; Alfian N. Wicaksono; James A. Covington; Marc A. Benninga; Nanne K. H. de Boer; Tim G. J. de Meij

doi:10.1093/cid/ciy383

Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

Daniel J. C. Berkhout^*, Britt J. van Keulen, Hendrik J. Niemarkt, Jet R. Bessem, Willem P. de Boode, Veerle Cossey, Neil Hoogenes, Christiaan V. Hulzebos, Ellen Klaver, Peter Andriessen, Anton H. van Kaam, Boris W. Kramer, Richard A. van Lingen, Aaron Schouten, Johannes B. van Goudoever, Daniel C. Vijlbrief, Mirjam M. van Weissenbruch, Alfian N. Wicaksono, James A. Covington, Marc A. BenningaNanne K. H. de Boer, Tim G. J. de Meij

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background. The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage.

Methods. In 9 neonatal intensive care units in the Netherlands and Belgium, fecal samples of preterm infants born at a gestational age

Results. In total, 843 preterm born infants (gestational age

Conclusions. Fecal VOC analysis allowed for preclinical discrimination between infants developing LOS and matched controls. Early detection of LOS may provide clinicians a window of opportunity for timely initiation of individualized therapeutic strategies aimed at prevention of sepsis, possibly improving LOS-related morbidity and mortality.

Original language	English
Pages (from-to)	70-77
Number of pages	8
Journal	Clinical Infectious Diseases
Volume	68
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciy383
Publication status	Published - 1 Jan 2019

Keywords

neonatology
volatile organic compound
late-onset sepsis
high-field asymmetric waveform ion mobility spectrometry
electronic nose
BLOOD
GUT
BACTERIA
INSIGHTS

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10.1093/cid/ciy383

Cite this

Berkhout, D. J. C., van Keulen, B. J., Niemarkt, H. J., Bessem, J. R., de Boode, W. P., Cossey, V., Hoogenes, N., Hulzebos, C. V., Klaver, E., Andriessen, P., van Kaam, A. H., Kramer, B. W., van Lingen, R. A., Schouten, A., van Goudoever, J. B., Vijlbrief, D. C., van Weissenbruch, M. M., Wicaksono, A. N., Covington, J. A., ... de Meij, T. G. J. (2019). Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study. Clinical Infectious Diseases, 68(1), 70-77. https://doi.org/10.1093/cid/ciy383

@article{b0e3a899c5774ea0beb2f731dc48770b,

title = "Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study",

abstract = "Background. The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage.Methods. In 9 neonatal intensive care units in the Netherlands and Belgium, fecal samples of preterm infants born at a gestational ageResults. In total, 843 preterm born infants (gestational ageConclusions. Fecal VOC analysis allowed for preclinical discrimination between infants developing LOS and matched controls. Early detection of LOS may provide clinicians a window of opportunity for timely initiation of individualized therapeutic strategies aimed at prevention of sepsis, possibly improving LOS-related morbidity and mortality.",

keywords = "neonatology, volatile organic compound, late-onset sepsis, high-field asymmetric waveform ion mobility spectrometry, electronic nose, BLOOD, GUT, BACTERIA, INSIGHTS",

author = "Berkhout, {Daniel J. C.} and {van Keulen}, {Britt J.} and Niemarkt, {Hendrik J.} and Bessem, {Jet R.} and {de Boode}, {Willem P.} and Veerle Cossey and Neil Hoogenes and Hulzebos, {Christiaan V.} and Ellen Klaver and Peter Andriessen and {van Kaam}, {Anton H.} and Kramer, {Boris W.} and {van Lingen}, {Richard A.} and Aaron Schouten and {van Goudoever}, {Johannes B.} and Vijlbrief, {Daniel C.} and {van Weissenbruch}, {Mirjam M.} and Wicaksono, {Alfian N.} and Covington, {James A.} and Benninga, {Marc A.} and {de Boer}, {Nanne K. H.} and {de Meij}, {Tim G. J.}",

note = "Funding Information: Disclaimer. None of the coauthors received an honorarium, grant or other form of payment for the production of this manuscript Funding. This work was supported by unrestricted grants from the Maag Lever Darm Stichting, Landelijke Vereniging van Crematoria (Dr. C.J. Vaillant Fonds), Zeldzame Ziekte Fonds and Christine Bader Stichting Irene Kinderziekenhuis. Publisher Copyright: {\textcopyright} 2018 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",

year = "2019",

month = jan,

day = "1",

doi = "10.1093/cid/ciy383",

language = "English",

volume = "68",

pages = "70--77",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "1",

}

Berkhout, DJC, van Keulen, BJ, Niemarkt, HJ, Bessem, JR, de Boode, WP, Cossey, V, Hoogenes, N, Hulzebos, CV, Klaver, E, Andriessen, P, van Kaam, AH, Kramer, BW, van Lingen, RA, Schouten, A, van Goudoever, JB, Vijlbrief, DC, van Weissenbruch, MM, Wicaksono, AN, Covington, JA, Benninga, MA, de Boer, NKH & de Meij, TGJ 2019, 'Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study', Clinical Infectious Diseases, vol. 68, no. 1, pp. 70-77. https://doi.org/10.1093/cid/ciy383

Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study. / Berkhout, Daniel J. C.; van Keulen, Britt J.; Niemarkt, Hendrik J. et al.
In: Clinical Infectious Diseases, Vol. 68, No. 1, 01.01.2019, p. 70-77.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis

T2 - A Prospective, Multicenter Cohort Study

AU - Berkhout, Daniel J. C.

AU - van Keulen, Britt J.

AU - Niemarkt, Hendrik J.

AU - Bessem, Jet R.

AU - de Boode, Willem P.

AU - Cossey, Veerle

AU - Hoogenes, Neil

AU - Hulzebos, Christiaan V.

AU - Klaver, Ellen

AU - Andriessen, Peter

AU - van Kaam, Anton H.

AU - Kramer, Boris W.

AU - van Lingen, Richard A.

AU - Schouten, Aaron

AU - van Goudoever, Johannes B.

AU - Vijlbrief, Daniel C.

AU - van Weissenbruch, Mirjam M.

AU - Wicaksono, Alfian N.

AU - Covington, James A.

AU - Benninga, Marc A.

AU - de Boer, Nanne K. H.

AU - de Meij, Tim G. J.

N1 - Funding Information: Disclaimer. None of the coauthors received an honorarium, grant or other form of payment for the production of this manuscript Funding. This work was supported by unrestricted grants from the Maag Lever Darm Stichting, Landelijke Vereniging van Crematoria (Dr. C.J. Vaillant Fonds), Zeldzame Ziekte Fonds and Christine Bader Stichting Irene Kinderziekenhuis. Publisher Copyright: © 2018 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background. The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage.Methods. In 9 neonatal intensive care units in the Netherlands and Belgium, fecal samples of preterm infants born at a gestational ageResults. In total, 843 preterm born infants (gestational ageConclusions. Fecal VOC analysis allowed for preclinical discrimination between infants developing LOS and matched controls. Early detection of LOS may provide clinicians a window of opportunity for timely initiation of individualized therapeutic strategies aimed at prevention of sepsis, possibly improving LOS-related morbidity and mortality.

AB - Background. The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage.Methods. In 9 neonatal intensive care units in the Netherlands and Belgium, fecal samples of preterm infants born at a gestational ageResults. In total, 843 preterm born infants (gestational ageConclusions. Fecal VOC analysis allowed for preclinical discrimination between infants developing LOS and matched controls. Early detection of LOS may provide clinicians a window of opportunity for timely initiation of individualized therapeutic strategies aimed at prevention of sepsis, possibly improving LOS-related morbidity and mortality.

KW - neonatology

KW - volatile organic compound

KW - late-onset sepsis

KW - high-field asymmetric waveform ion mobility spectrometry

KW - electronic nose

KW - BLOOD

KW - GUT

KW - BACTERIA

KW - INSIGHTS

U2 - 10.1093/cid/ciy383

DO - 10.1093/cid/ciy383

M3 - Article

C2 - 29931245

SN - 1058-4838

VL - 68

SP - 70

EP - 77

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -