Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

S. R. Ellis*, J. Soltwisch, M. R. L. Paine, K. Dreisewerd, R. M. A. Heeren

*Corresponding author for this work

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Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to B100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

Original languageEnglish
Pages (from-to)7246-7249
Number of pages4
JournalChemical Communications
Issue number53
Publication statusPublished - 7 Jul 2017



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