Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

Maarten H. G. Heusinkveld; Wouter Huberts; Joost Lumens; Theo Arts; Tammo Delhaas; Koen D. Reesink

doi:10.1371/journal.pcbi.1007173

Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

Maarten H. G. Heusinkveld^*, Wouter Huberts, Joost Lumens, Theo Arts, Tammo Delhaas, Koen D. Reesink

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Web of Science)

Abstract

We developed a whole-circulation computational model by integrating a transmission line (TL) model describing vascular wave transmission into the established CircAdapt platform of whole-heart mechanics. In the present paper, we verify the numerical framework of our TL model by benchmark comparison to a previously validated pulse wave propagation (PWP) model. Additionally, we showcase the integrated CircAdapt-TL model, which now includes the heart as well as extensive arterial and venous trees with terminal impedances. We present CircAdapt-TL haemodynamics simulations of: 1) a systemic normotensive situation and 2) a systemic hypertensive situation. In the TL-PWP benchmark comparison we found good agreement regarding pressure and flow waveforms (relative errors

Original language	English
Article number	1007173
Number of pages	21
Journal	PLoS Computational Biology
Volume	15
Issue number	7
DOIs	https://doi.org/10.1371/journal.pcbi.1007173
Publication status	Published - Jul 2019

Keywords

PULSE-WAVE PROPAGATION
BLOOD-FLOW
SIMULATION
PRESSURE
WALL
REFLECTIONS
VELOCITY

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10.1371/journal.pcbi.1007173

Cite this

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title = "Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction",

abstract = "We developed a whole-circulation computational model by integrating a transmission line (TL) model describing vascular wave transmission into the established CircAdapt platform of whole-heart mechanics. In the present paper, we verify the numerical framework of our TL model by benchmark comparison to a previously validated pulse wave propagation (PWP) model. Additionally, we showcase the integrated CircAdapt-TL model, which now includes the heart as well as extensive arterial and venous trees with terminal impedances. We present CircAdapt-TL haemodynamics simulations of: 1) a systemic normotensive situation and 2) a systemic hypertensive situation. In the TL-PWP benchmark comparison we found good agreement regarding pressure and flow waveforms (relative errors",

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T2 - A computational tool to examine heart-vessel interaction

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AU - Huberts, Wouter

AU - Lumens, Joost

AU - Arts, Theo

AU - Delhaas, Tammo

AU - Reesink, Koen D.

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KW - PRESSURE

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KW - REFLECTIONS

KW - VELOCITY

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