Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction

Maarten H. G. Heusinkveld*, Wouter Huberts, Joost Lumens, Theo Arts, Tammo Delhaas, Koen D. Reesink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

We developed a whole-circulation computational model by integrating a transmission line (TL) model describing vascular wave transmission into the established CircAdapt platform of whole-heart mechanics. In the present paper, we verify the numerical framework of our TL model by benchmark comparison to a previously validated pulse wave propagation (PWP) model. Additionally, we showcase the integrated CircAdapt-TL model, which now includes the heart as well as extensive arterial and venous trees with terminal impedances. We present CircAdapt-TL haemodynamics simulations of: 1) a systemic normotensive situation and 2) a systemic hypertensive situation. In the TL-PWP benchmark comparison we found good agreement regarding pressure and flow waveforms (relative errors

Original languageEnglish
Article number1007173
Number of pages21
JournalPLoS Computational Biology
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 2019

Keywords

  • PULSE-WAVE PROPAGATION
  • BLOOD-FLOW
  • SIMULATION
  • PRESSURE
  • WALL
  • REFLECTIONS
  • VELOCITY

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