Abstract
We developed a whole-circulation computational model by integrating a transmission line (TL) model describing vascular wave transmission into the established CircAdapt platform of whole-heart mechanics. In the present paper, we verify the numerical framework of our TL model by benchmark comparison to a previously validated pulse wave propagation (PWP) model. Additionally, we showcase the integrated CircAdapt-TL model, which now includes the heart as well as extensive arterial and venous trees with terminal impedances. We present CircAdapt-TL haemodynamics simulations of: 1) a systemic normotensive situation and 2) a systemic hypertensive situation. In the TL-PWP benchmark comparison we found good agreement regarding pressure and flow waveforms (relative errors
Original language | English |
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Article number | 1007173 |
Number of pages | 21 |
Journal | PLoS Computational Biology |
Volume | 15 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2019 |
Keywords
- PULSE-WAVE PROPAGATION
- BLOOD-FLOW
- SIMULATION
- PRESSURE
- WALL
- REFLECTIONS
- VELOCITY