Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells

Sophie E. van der Krieken; Herman E. Popeijus; Igor Bendik; Bettina Bohlendorf; Maurice C. J. M. Konings; Jehad Tayyeb; Ronald P. Mensink; Jogchum Plat

doi:10.1002/lipd.12116

Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells

Sophie E. van der Krieken, Herman E. Popeijus^*, Igor Bendik, Bettina Bohlendorf, Maurice C. J. M. Konings, Jehad Tayyeb, Ronald P. Mensink, Jogchum Plat

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1021-1030
Number of pages	10
Journal	Lipids
Volume	53
Issue number	11-12
DOIs	https://doi.org/10.1002/lipd.12116
Publication status	Published - 2018

Keywords

9(S)-HOTrE
Apolipoprotein A-I
Cymarin
Fatty acids
High-density lipoprotein
Peroxisome proliferator-activated receptor alpha
qPCR
Transactivation
APOA-I
CHOLESTEROL EFFLUX
HDL CHOLESTEROL
BET-INHIBITOR
PROTEIN
RISK
ALOX5AP
DIGOXIN
TARGET

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van der Krieken, S. E., Popeijus, H. E., Bendik, I., Bohlendorf, B., Konings, M. C. J. M., Tayyeb, J., Mensink, R. P., & Plat, J. (2018). Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells. Lipids, 53(11-12), 1021-1030. https://doi.org/10.1002/lipd.12116

van der Krieken, Sophie E. ; Popeijus, Herman E. ; Bendik, Igor ; Bohlendorf, Bettina ; Konings, Maurice C. J. M. ; Tayyeb, Jehad ; Mensink, Ronald P. ; Plat, Jogchum. / Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells. In: Lipids. 2018 ; Vol. 53, No. 11-12. pp. 1021-1030.

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title = "Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells",

keywords = "9(S)-HOTrE, Apolipoprotein A-I, Cymarin, Fatty acids, High-density lipoprotein, Peroxisome proliferator-activated receptor alpha, qPCR, Transactivation, APOA-I, CHOLESTEROL EFFLUX, HDL CHOLESTEROL, BET-INHIBITOR, PROTEIN, RISK, ALOX5AP, DIGOXIN, TARGET",

author = "{van der Krieken}, {Sophie E.} and Popeijus, {Herman E.} and Igor Bendik and Bettina Bohlendorf and Konings, {Maurice C. J. M.} and Jehad Tayyeb and Mensink, {Ronald P.} and Jogchum Plat",

year = "2018",

doi = "10.1002/lipd.12116",

language = "English",

volume = "53",

pages = "1021--1030",

journal = "Lipids",

issn = "0024-4201",

publisher = "Wiley",

number = "11-12",

}

van der Krieken, SE, Popeijus, HE, Bendik, I, Bohlendorf, B, Konings, MCJM, Tayyeb, J , Mensink, RP & Plat, J 2018, 'Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells', Lipids, vol. 53, no. 11-12, pp. 1021-1030. https://doi.org/10.1002/lipd.12116

Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells. / van der Krieken, Sophie E.; Popeijus, Herman E.; Bendik, Igor; Bohlendorf, Bettina; Konings, Maurice C. J. M.; Tayyeb, Jehad ; Mensink, Ronald P.; Plat, Jogchum.

In: Lipids, Vol. 53, No. 11-12, 2018, p. 1021-1030.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells

AU - van der Krieken, Sophie E.

AU - Popeijus, Herman E.

AU - Bendik, Igor

AU - Bohlendorf, Bettina

AU - Konings, Maurice C. J. M.

AU - Tayyeb, Jehad

AU - Mensink, Ronald P.

AU - Plat, Jogchum

PY - 2018

Y1 - 2018

KW - 9(S)-HOTrE

KW - Apolipoprotein A-I

KW - Cymarin

KW - Fatty acids

KW - High-density lipoprotein

KW - Peroxisome proliferator-activated receptor alpha

KW - qPCR

KW - Transactivation

KW - APOA-I

KW - CHOLESTEROL EFFLUX

KW - HDL CHOLESTEROL

KW - BET-INHIBITOR

KW - PROTEIN

KW - RISK

KW - ALOX5AP

KW - DIGOXIN

KW - TARGET

U2 - 10.1002/lipd.12116

DO - 10.1002/lipd.12116

M3 - Article

VL - 53

SP - 1021

EP - 1030

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 11-12

ER -

van der Krieken SE, Popeijus HE, Bendik I, Bohlendorf B, Konings MCJM, Tayyeb J et al. Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells. Lipids. 2018;53(11-12):1021-1030. https://doi.org/10.1002/lipd.12116