Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor alpha Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells

Sophie E. van der Krieken, Herman E. Popeijus*, Igor Bendik, Bettina Bohlendorf, Maurice C. J. M. Konings, Jehad Tayyeb, Ronald P. Mensink, Jogchum Plat

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1021-1030
Number of pages10
JournalLipids
Volume53
Issue number11-12
DOIs
Publication statusPublished - 2018

Keywords

  • 9(S)-HOTrE
  • Apolipoprotein A-I
  • Cymarin
  • Fatty acids
  • High-density lipoprotein
  • Peroxisome proliferator-activated receptor alpha
  • qPCR
  • Transactivation
  • APOA-I
  • CHOLESTEROL EFFLUX
  • HDL CHOLESTEROL
  • BET-INHIBITOR
  • PROTEIN
  • RISK
  • ALOX5AP
  • DIGOXIN
  • TARGET

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