Lacosamide Inhibition of Na(V)1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

J.I.R. Labau, M. Alsaloum, M. Estacion, B. Tanaka, F.B. Dib-Hajj*, G. Lauria, H.J.M. Smeets, C.G. Faber, S. Dib-Hajj*, S.G. Waxman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number791740
Number of pages17
JournalFrontiers in Pharmacology
Volume12
DOIs
Publication statusPublished - 21 Dec 2021

Keywords

  • voltage-gated sodium channels
  • local anesthetics
  • manual and automated electrophysiolgy
  • voltage-sensing domain
  • molecular docking
  • GATED SODIUM-CHANNELS
  • QUALITY-OF-LIFE
  • CHRONIC PAIN
  • NEUROPATHIC PAIN
  • DRUG-BINDING
  • SLOW INACTIVATION
  • LOCAL-ANESTHETICS
  • PREVALENCE
  • LIDOCAINE
  • MECHANISM

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