Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4(+) T Cells from Patients with Vogt-Koyanagi-Harada Syndrome

Liming Mao*, Peizeng Yang, Shengping Hou, Fuzhen Li, Aize Kijlstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)

Abstract

Vogt-Koyanagi-Harada (VKH) syndrome is a systemic autoimmune disease. CD4(+) T cells have been shown to be involved in autoimmune diseases including VKH syndrome. To screen aberrantly expressed membrane proteins in CD4(+) T cell from patients with active VKH syndrome, blood samples were taken from five patients with active VKH syndrome and five healthy individuals. A label-free quantitative proteomic strategy was used to identify the differently expressed proteins between the two groups. The results revealed that the expression of 102 peptides was significantly altered (p
Original languageEnglish
Pages (from-to)9
JournalPLOS ONE
Volume6
Issue number1
DOIs
Publication statusPublished - 28 Jan 2011

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