Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4(+) T Cells from Patients with Vogt-Koyanagi-Harada Syndrome

Liming Mao; Peizeng Yang; Shengping Hou; Fuzhen Li; Aize Kijlstra

doi:10.1371/journal.pone.0014616

Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4(+) T Cells from Patients with Vogt-Koyanagi-Harada Syndrome

Liming Mao^*, Peizeng Yang, Shengping Hou, Fuzhen Li, Aize Kijlstra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Vogt-Koyanagi-Harada (VKH) syndrome is a systemic autoimmune disease. CD4(+) T cells have been shown to be involved in autoimmune diseases including VKH syndrome. To screen aberrantly expressed membrane proteins in CD4(+) T cell from patients with active VKH syndrome, blood samples were taken from five patients with active VKH syndrome and five healthy individuals. A label-free quantitative proteomic strategy was used to identify the differently expressed proteins between the two groups. The results revealed that the expression of 102 peptides was significantly altered (p

Original language	English
Pages (from-to)	9
Journal	PLOS ONE
Volume	6
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0014616
Publication status	Published - 28 Jan 2011

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10.1371/journal.pone.0014616Licence: CC BY

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abstract = "Vogt-Koyanagi-Harada (VKH) syndrome is a systemic autoimmune disease. CD4(+) T cells have been shown to be involved in autoimmune diseases including VKH syndrome. To screen aberrantly expressed membrane proteins in CD4(+) T cell from patients with active VKH syndrome, blood samples were taken from five patients with active VKH syndrome and five healthy individuals. A label-free quantitative proteomic strategy was used to identify the differently expressed proteins between the two groups. The results revealed that the expression of 102 peptides was significantly altered (p",

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AU - Kijlstra, Aize

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AB - Vogt-Koyanagi-Harada (VKH) syndrome is a systemic autoimmune disease. CD4(+) T cells have been shown to be involved in autoimmune diseases including VKH syndrome. To screen aberrantly expressed membrane proteins in CD4(+) T cell from patients with active VKH syndrome, blood samples were taken from five patients with active VKH syndrome and five healthy individuals. A label-free quantitative proteomic strategy was used to identify the differently expressed proteins between the two groups. The results revealed that the expression of 102 peptides was significantly altered (p

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Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4(+) T Cells from Patients with Vogt-Koyanagi-Harada Syndrome

Abstract

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