Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf

Marcel J H Ariës; Joop P van den Bergh; Martijn Beudel; Wim Boersma; Tom Dormans; Renee A Douma; Annet Eerens; Paul W G Elbers; Lucas M Fleuren; Niels C Gritters van den Oever; Lianne de Haan; Iwan J C C van der Horst; Shi Hu; Deborah Hubers; Marcus L F Janssen; Martijn de Kruif; Pieter L Kubben; Sander M J van Kuijk; Peter G Noordzij; Maarten Ottenhoff; Dan A I Piña-Fuentes; Wouter V Potters; Auke C Reidinga; Roos S C Renckens; Sander Rigter; Daisy Rusch; Michiel Schinkel; Kim C E Sigaloff; Suat Simsek; Patricia Stassen; Robert Stassen; Rajat M Thomas; Guido A van Wingen; Anton Vonk Noordegraaf; Max Welling; W Joost Wiersinga; Marije D J Wolvers; Caroline E Wyers

Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf

Translated title of the contribution: Clinical course of COVID-19 in the Netherlands: an overview of 2607 patients in hospital during the first wave

Marcel J H Ariës, Joop P van den Bergh, Martijn Beudel, Wim Boersma, Tom Dormans, Renee A Douma, Annet Eerens, Paul W G Elbers, Lucas M Fleuren, Niels C Gritters van den Oever, Lianne de Haan, Iwan J C C van der Horst, Shi Hu, Deborah Hubers, Marcus L F Janssen, Martijn de Kruif, Pieter L Kubben, Sander M J van Kuijk, Peter G Noordzij, Maarten OttenhoffDan A I Piña-Fuentes, Wouter V Potters, Auke C Reidinga, Roos S C Renckens, Sander Rigter, Daisy Rusch, Michiel Schinkel, Kim C E Sigaloff, Suat Simsek, Patricia Stassen, Robert Stassen, Rajat M Thomas, Guido A van Wingen, Anton Vonk Noordegraaf, Max Welling, W Joost Wiersinga, Marije D J Wolvers, Caroline E Wyers

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands.

DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported.

METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission.

RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels.

CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.

Translated title of the contribution	Clinical course of COVID-19 in the Netherlands: an overview of 2607 patients in hospital during the first wave
Original language	Dutch
Article number	D5085
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	165
Issue number	3
Publication status	Published - 11 Jan 2021

Keywords

Age Factors
Aged
COVID-19/epidemiology
Cardiovascular Diseases/epidemiology
Comorbidity
Critical Care/methods
Diagnostic Tests, Routine/methods
Female
Hospital Mortality
Humans
Kaplan-Meier Estimate
Male
Netherlands/epidemiology
Risk Factors
SARS-CoV-2/isolation & purification
Severity of Illness Index

Access to Document

Full text Final published version, 375 KBLicence: Taverne

https://www.ntvg.nl/artikelen/klinisch-beloop-van-covid-19-nederlandLicence: Unspecified
https://pubmed.ncbi.nlm.nih.gov/33651497/

Cite this

Ariës, M. J. H., van den Bergh, J. P., Beudel, M., Boersma, W., Dormans, T., Douma, R. A., Eerens, A., Elbers, P. W. G., Fleuren, L. M., Gritters van den Oever, N. C., de Haan, L., van der Horst, I. J. C. C., Hu, S., Hubers, D., Janssen, M. L. F., de Kruif, M., Kubben, P. L., van Kuijk, S. M. J., Noordzij, P. G., ... Wyers, C. E. (2021). Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf. Nederlands Tijdschrift voor Geneeskunde, 165(3), Article D5085. https://www.ntvg.nl/artikelen/klinisch-beloop-van-covid-19-nederland

@article{557efd610223493bb207076473ab4a0b,

title = "Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispati{\"e}nten uit de eerste golf",

abstract = "OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands.DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported.METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission.RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels.CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.",

keywords = "Age Factors, Aged, COVID-19/epidemiology, Cardiovascular Diseases/epidemiology, Comorbidity, Critical Care/methods, Diagnostic Tests, Routine/methods, Female, Hospital Mortality, Humans, Kaplan-Meier Estimate, Male, Netherlands/epidemiology, Risk Factors, SARS-CoV-2/isolation & purification, Severity of Illness Index",

author = "Ari{\"e}s, {Marcel J H} and {van den Bergh}, {Joop P} and Martijn Beudel and Wim Boersma and Tom Dormans and Douma, {Renee A} and Annet Eerens and Elbers, {Paul W G} and Fleuren, {Lucas M} and {Gritters van den Oever}, {Niels C} and {de Haan}, Lianne and {van der Horst}, {Iwan J C C} and Shi Hu and Deborah Hubers and Janssen, {Marcus L F} and {de Kruif}, Martijn and Kubben, {Pieter L} and {van Kuijk}, {Sander M J} and Noordzij, {Peter G} and Maarten Ottenhoff and Pi{\~n}a-Fuentes, {Dan A I} and Potters, {Wouter V} and Reidinga, {Auke C} and Renckens, {Roos S C} and Sander Rigter and Daisy Rusch and Michiel Schinkel and Sigaloff, {Kim C E} and Suat Simsek and Patricia Stassen and Robert Stassen and Thomas, {Rajat M} and {van Wingen}, {Guido A} and {Vonk Noordegraaf}, Anton and Max Welling and Wiersinga, {W Joost} and Wolvers, {Marije D J} and Wyers, {Caroline E}",

year = "2021",

month = jan,

day = "11",

language = "Dutch",

volume = "165",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu van Loghum",

number = "3",

}

Ariës, MJH , van den Bergh, JP, Beudel, M, Boersma, W, Dormans, T, Douma, RA, Eerens, A, Elbers, PWG, Fleuren, LM, Gritters van den Oever, NC, de Haan, L, van der Horst, IJCC, Hu, S, Hubers, D, Janssen, MLF, de Kruif, M, Kubben, PL , van Kuijk, SMJ, Noordzij, PG, Ottenhoff, M, Piña-Fuentes, DAI, Potters, WV, Reidinga, AC, Renckens, RSC, Rigter, S, Rusch, D, Schinkel, M, Sigaloff, KCE, Simsek, S, Stassen, P, Stassen, R, Thomas, RM, van Wingen, GA, Vonk Noordegraaf, A, Welling, M, Wiersinga, WJ, Wolvers, MDJ & Wyers, CE 2021, 'Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf', Nederlands Tijdschrift voor Geneeskunde, vol. 165, no. 3, D5085. <https://www.ntvg.nl/artikelen/klinisch-beloop-van-covid-19-nederland>

TY - JOUR

T1 - Klinisch beloop van covid-19 in Nederland

T2 - Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf

AU - Ariës, Marcel J H

AU - van den Bergh, Joop P

AU - Beudel, Martijn

AU - Boersma, Wim

AU - Dormans, Tom

AU - Douma, Renee A

AU - Eerens, Annet

AU - Elbers, Paul W G

AU - Fleuren, Lucas M

AU - Gritters van den Oever, Niels C

AU - de Haan, Lianne

AU - van der Horst, Iwan J C C

AU - Hu, Shi

AU - Hubers, Deborah

AU - Janssen, Marcus L F

AU - de Kruif, Martijn

AU - Kubben, Pieter L

AU - van Kuijk, Sander M J

AU - Noordzij, Peter G

AU - Ottenhoff, Maarten

AU - Piña-Fuentes, Dan A I

AU - Potters, Wouter V

AU - Reidinga, Auke C

AU - Renckens, Roos S C

AU - Rigter, Sander

AU - Rusch, Daisy

AU - Schinkel, Michiel

AU - Sigaloff, Kim C E

AU - Simsek, Suat

AU - Stassen, Patricia

AU - Stassen, Robert

AU - Thomas, Rajat M

AU - van Wingen, Guido A

AU - Vonk Noordegraaf, Anton

AU - Welling, Max

AU - Wiersinga, W Joost

AU - Wolvers, Marije D J

AU - Wyers, Caroline E

PY - 2021/1/11

Y1 - 2021/1/11

N2 - OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands.DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported.METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission.RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels.CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.

AB - OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands.DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported.METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission.RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels.CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.

KW - Age Factors

KW - Aged

KW - COVID-19/epidemiology

KW - Cardiovascular Diseases/epidemiology

KW - Comorbidity

KW - Critical Care/methods

KW - Diagnostic Tests, Routine/methods

KW - Female

KW - Hospital Mortality

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Netherlands/epidemiology

KW - Risk Factors

KW - SARS-CoV-2/isolation & purification

KW - Severity of Illness Index

M3 - Article

C2 - 33651497

SN - 0028-2162

VL - 165

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 3

M1 - D5085

ER -