Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential

A.B. Marquez, E.P.C. van der Vorst*, S.L. Maas*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

3 Citations (Web of Science)

Abstract

The search to improve therapies to prevent or treat cardiovascular diseases (CVDs) rages on, as CVDs remain a leading cause of death worldwide. Here, the main cause of CVDs, atherosclerosis, and its prevention, take center stage. Chemokines and their receptors have long been known to play an important role in the pathophysiological development of atherosclerosis. Their role extends from the initiation to the progression, and even the potential regression of atherosclerotic lesions. These important regulators in atherosclerosis are therefore an obvious target in the development of therapeutic strategies. A plethora of preclinical studies have assessed various possibilities for targeting chemokine signaling via various approaches, including competitive ligands and microRNAs, which have shown promising results in ameliorating atherosclerosis. Developments in the field also include detailed imaging with tracers that target specific chemokine receptors. Lastly, clinical trials revealed the potential of various therapies but still require further investigation before commencing clinical use. Although there is still a lot to be learned and investigated, it is clear that chemokines and their receptors present attractive yet extremely complex therapeutic targets. Therefore, this review will serve to provide a general overview of the connection between various chemokines and their receptors with atherosclerosis. The different developments, including mouse models and clinical trials that tackle this complex interplay will also be explored.
Original languageEnglish
Article number3825
Number of pages25
JournalJournal of Clinical Medicine
Volume10
Issue number17
DOIs
Publication statusPublished - 1 Sep 2021

Keywords

  • chemokines
  • chemokine receptors
  • cardiovascular disease
  • atherosclerosis
  • RECEPTOR 4 EXPRESSION
  • REDUCES ATHEROSCLEROSIS
  • PLATELET CHEMOKINES
  • PROMOTES ATHEROSCLEROSIS
  • LIMITS ATHEROSCLEROSIS
  • RHEUMATOID-ARTHRITIS
  • PLAQUE-FORMATION
  • LESION FORMATION
  • DENDRITIC CELLS
  • NUCLEAR-FACTOR

Cite this