Key Characteristics Approach to Carcinogenic Hazard Identification

Kathryn Z Guyton; Linda Rieswijk; Amy Wang; Weihsueh A Chiu; Martyn T Smith

doi:10.1021/acs.chemrestox.8b00321

Key Characteristics Approach to Carcinogenic Hazard Identification

Kathryn Z Guyton
, Linda Rieswijk
, Amy Wang
, Weihsueh A Chiu
, Martyn T Smith^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.

Original language	English
Pages (from-to)	1290-1292
Number of pages	3
Journal	Chemical Research in Toxicology
Volume	31
Issue number	12
DOIs	https://doi.org/10.1021/acs.chemrestox.8b00321
Publication status	Published - 17 Dec 2018

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title = "Key Characteristics Approach to Carcinogenic Hazard Identification",

abstract = "Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.",

author = "Guyton, \{Kathryn Z\} and Linda Rieswijk and Amy Wang and Chiu, \{Weihsueh A\} and Smith, \{Martyn T\}",

year = "2018",

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language = "English",

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AU - Guyton, Kathryn Z

AU - Rieswijk, Linda

AU - Wang, Amy

AU - Chiu, Weihsueh A

AU - Smith, Martyn T

PY - 2018/12/17

Y1 - 2018/12/17

N2 - Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.

AB - Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.

U2 - 10.1021/acs.chemrestox.8b00321

DO - 10.1021/acs.chemrestox.8b00321

M3 - Article

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SN - 0893-228X

VL - 31

SP - 1290

EP - 1292

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

IS - 12

ER -

Key Characteristics Approach to Carcinogenic Hazard Identification

Abstract

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