Keeping warm in the cold : human brown adipose tissue upon cold acclimation

A.A.J.J. van der Lans

Research output: ThesisDoctoral ThesisInternal

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This dissertation studied the effects of cold acclimation on slim and overweight/obese test subjects. Cold acclimation induced an increase in the production of brown adipose tissue. After stimulation, brown adipose tissue induced the conversion of glucose and fats into extra heat. Cold acclimation also increased energy expenditure without shivering. A significant relation was found between brown adipose tissue activity and energy expenditure without shivering. Furthermore, slim test subjects were found to grow accustomed to cold. Regular exposure to cold can, therefore, serve as a means of increasing energy expenditure, which may have favourable effects on weight maintenance.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • van Marken Lichtenbelt, Wouter, Supervisor
  • Schrauwen, Patrick, Supervisor
Award date3 Jul 2015
Place of Publication's-Hertogenbosch
Print ISBNs9789462951433
Publication statusPublished - 2015


  • overweight
  • brown adipose tissue
  • cold acclimation
  • energy expenditure

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