Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (TürkSch): Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample: Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample

Umut Kirli*, Tolga Binbay, Hayriye Elbi, Marjan Drukker, Bulent Kayahan, Ferda Ozkinay, Huseyin Onay, Koksal Alptekin, Jim van Os

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Objective: TurkSch is a prospective, longitudinal study in a representative community sample (Izmir, Turkey), consisting of several data collection stages, to screen and follow-up mental health outcomes, with a special focus on the extended and transdiagnostic psychosis phenotype. The aim of the present paper is to describe the research methodology, data collection results, and associations with noncontact and refusal in the longitudinal arm.

Methods: Households were contacted in a multistage clustered probability sampling frame, covering 11 districts and 302 neighborhoods at baseline (n = 4,011) and at 6-year follow-up (n = 2,185). Both at baseline and at follow-up, participants were interviewed with the Composite International Diagnostic Interview. Participants with probable psychotic disorder were reinterviewed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID)-I either at the hospital or at the participant's residence. Relevant neighborhood-level measures were assessed in a separate sample (n = 5,124) in addition to individual-level measures. Candidate gene-by-environment interactions were investigated using two nested case-control studies.

Results: Individuals with a mental health problem had lower refusal rates. Older and lower educated individuals had a lower probability of noncontact.

Discussion: The TurkSch study has an advanced design to meet the challenges of evaluating the multidimensional etiological and phenomenological nature of the extended and transdiagnostic psychosis phenotype.

Original languageEnglish
Article number554
Pages (from-to)1-12
Number of pages12
JournalFrontiers in Psychiatry
Volume10
DOIs
Publication statusPublished - 7 Aug 2019

Keywords

  • extended psychosis phenotype
  • transdiagnostic psychosis phenotype
  • epidemiology
  • representative community-based sample
  • neighborhood-level measures
  • gene-environment interactions
  • INTERNATIONAL DIAGNOSTIC INTERVIEW
  • ULTRA-HIGH RISK
  • VAL66MET POLYMORPHISM
  • SUSCEPTIBILITY GENE
  • NEUREGULIN 1
  • SCHIZOPHRENIA
  • EXPERIENCES
  • ASSOCIATION
  • SYMPTOMS
  • DISORDER

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