Is this for real? The role of advanced placebo technology when using Transcranial Magnetic Stimulation in clinical practice

Georgios Mikellides

Research output: ThesisDoctoral ThesisInternal

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Abstract

This thesis offers a comprehensive exploration of repetitive Transcranial Magnetic Stimulation (rTMS) as a potential treatment avenue for neuropsychiatric disorders, encompassing depression, nicotine addiction, epilepsy, and Parkinson's disease. Through a double-blind randomized study, a retrospective study, and case reports, this research highlights rTMS' effectiveness, considering placebo effects and alternative therapies like ketamine treatment. Notably, a study on smoking cessation demonstrates aiTBS's efficacy in reducing cigarette consumption and cravings, while investigations into TRD (treatment-resistant depression) reveal comparable benefits between rTMS and IM ketamine treatments. Case reports on epilepsy and Parkinson's disease showcase positive outcomes, emphasizing potential rTMS benefits in persistent neurological conditions. Addressing safety concerns, the thesis stresses careful patient selection and monitoring during rTMS. This comprehensive work advances understanding, advocating for rTMS as a valuable neuropsychiatric treatment, though further research is required for broader applications and improved patient outcomes.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Sack, Alexander, Supervisor
  • Schuhmann, Teresa, Supervisor
Award date11 Sept 2023
Place of PublicationMaastricht
Publisher
Print ISBNs9789464694284
DOIs
Publication statusPublished - 2023

Keywords

  • ketamine
  • repetitive transcranial magnetic stimulation
  • treatment-resistant depression
  • nicotine addiction

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