Is TAK1 a Direct Upstream Kinase of AMPK?

Dietbert Neumann*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

45 Citations (Web of Science)

Abstract

Alongside Liver kinase B1 (LKB1) and Ca2+/Calmodulin-dependent protein kinase kinase 2 (CaMKK2), Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) has been suggested as a direct upstream kinase of AMP-activated protein kinase (AMPK). Several subsequent studies have reported on the TAK1-AMPK relationship, but the interpretation of the respective data has led to conflicting views. Therefore, to date the acceptance of TAK1 as a genuine AMPK kinase is lagging behind. This review provides with argumentation, whether or not TAK1 functions as a direct upstream kinase of AMPK. Several specific open questions that may have precluded the consensus are discussed based on available data. In brief, TAK1 can function as direct AMPK upstream kinase in specific contexts and in response to a subset of TAK1 activating stimuli. Further research is needed to define the intricate signals that are conditional for TAK1 to phosphorylate and activate AMPK at T172.
Original languageEnglish
Article number2412
Number of pages8
JournalInternational journal of molecular sciences
Volume19
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • TAK1
  • AMPK
  • phosphorylation
  • AMPK kinase
  • ACTIVATED PROTEIN-KINASE
  • ENERGY-SENSOR
  • SIGNALING PATHWAYS
  • INDUCED APOPTOSIS
  • EPITHELIAL-CELLS
  • BETA
  • AUTOPHAGY
  • CANCER
  • BALANCE
  • SNF1

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