Is nondipping in 24 h ambulatory blood pressure related to cognitive dysfunction?

Martin P.J. van Boxtel, Carlo Gaillard, Peter J. Houx, F. Buntinx, Jellemer Jolles

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Objective
    Associations between the outcome of 24 h ambulatory monitoring and cognitive performance were studied in order to evaluate the potential relevance of ambulant blood pressure status to brain function. It was hypothesized that a small daytime–night-time difference in mean blood pressure (nondipping) is associated with reduced cognitive performance, in line with studies in hypertensive subjects that have reported associations between nondipping and target-organ damage.

    Methods
    The study followed a cross-sectional design and was part of a larger research programme on determinants of cognitive aging (Maastricht Aging Study, MAAS). A group of 115 community residents aged 28–82 years was recruited from a general practice population and screened for cardiovascular events and medication use. All underwent 24 h blood pressure monitoring. Cognitive performance was measured with tests of verbal memory, attention, simple speed and information processing speed.

    Results
    Mean daytime or night-time levels of both systolic and diastolic blood pressure were unrelated to cognitive outcome, when age, sex and educational level were controlled for. Differences between mean daytime and night-time blood pressure (based on both narrow and wide measurement intervals for day and night-time periods) were positively associated with memory function (5–9% of additional variance explained) and one sporadic positive association was found on the sensorimotor speed score (4%). Nondippers (n = 15) showed lower levels of both memory and sensorimotor speed scores.

    Conclusions
    Ambulatory blood pressure status was not associated with cognitive performance. A reduced nocturnal blood pressure drop was associated with quite specific cognitive deficits, but the underlying mechanism remains to be determined.
    Original languageEnglish
    Pages (from-to)1425-1432
    Number of pages8
    JournalJournal of Hypertension
    Volume16
    Issue number10
    DOIs
    Publication statusPublished - 1 Jan 1998

    Cite this