Is a Schizo-Obsessive Subtype Associated With Cognitive Impairment? Results From a Large Cross-sectional Study in Patients With Psychosis and Their Unaffected Relatives

GRP Investigators, Jim van Os, Richard Bruggeman, Inez Germeys

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The current study investigated whether candidate cognitive endophenotypes may be used to validate a schizo-obsessive subtype. Using within-subject random effect regression analyses and cross-trait cross-relative analyses, we evaluated the association between obsessive-compulsive symptoms (OCSs) and cognitive performance in 984 patients with nonaffective psychosis (22.5% with OCSs), 973 unaffected siblings (7.7% with OCSs), 851 parents (4.2% with OCSs), and 573 controls (4.5% with OCSs). No significant within-subject associations between OCSs and cognitive functioning were found for patients and siblings. Severity of OCSs was associated with worse set-shifting ability in parents and worse processing speed in controls, but effect sizes were small (0.10 and 0.05 respectively). Cross-trait cross-relative analyses yielded no significant results. Contrary to our expectations, neither within-subject analyses nor cross-relative analyses yielded a clear association between OCSs and cognitive performance. Results do not support a schizo-obsessive subtype associated with cognitive impairment.
Original languageEnglish
Pages (from-to)30-35
JournalJournal of Nervous and Mental Disease
Issue number1
Publication statusPublished - Jan 2013


  • Schizophrenia
  • obsessive-compulsive symptoms
  • neuropsychology
  • siblings
  • endophenotype

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