Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

J. Palzer, L. Eckstein, I. Slabu, O. Reisen, U.P. Neumann, A.A. Roeth*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

7 Citations (Web of Science)

Abstract

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Neel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.
Original languageEnglish
Article number3013
Number of pages16
JournalNanomaterials
Volume11
Issue number11
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • CANCER-THERAPY
  • CHEMOHYPERTHERMIA
  • CONTRAST
  • DELIVERY
  • DOCETAXEL-EMBEDDED MAGNETOLIPOSOMES
  • HEPATOCELLULAR-CARCINOMA
  • LIVER-DISEASE
  • MAGNETIC NANOPARTICLES
  • MODEL
  • PHOTOTHERMAL ABLATION
  • cancer
  • iron oxide nanoparticles
  • magnetic fluid hyperthermia
  • photothermal therapy
  • THERAPY
  • CANCER STATISTICS

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